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胰腺癌的诊断。血清学标志物。

Diagnosis of pancreatic cancer. Serological markers.

作者信息

Satake K

机构信息

First Department of Surgery, Osaka City University, Medical School, Japan.

出版信息

Int J Pancreatol. 1991 Summer;9:93-8. doi: 10.1007/BF02925584.

DOI:10.1007/BF02925584
PMID:1744453
Abstract

Many serological markers that are widely used for delecting pancreatic cancer are discussed. Some are good indicators, but others are not. Among them, CA19-9 and SPan-1 radioimmunoassays have a higher sensitivity and specificity. However, these markers are neither tumor-specific nor pancreatic cancer-specific. Accurate understanding of their measurement made it possible to diagnose pancreatic cancer, even when the cancer was small, and to monitor the patients after treatment.

摘要

本文讨论了许多广泛用于检测胰腺癌的血清学标志物。有些是很好的指标,但有些则不然。其中,CA19-9和SPan-1放射免疫测定具有较高的敏感性和特异性。然而,这些标志物既不是肿瘤特异性的,也不是胰腺癌特异性的。准确理解它们的检测结果有助于诊断胰腺癌,即使癌症还很小,也有助于治疗后对患者进行监测。

相似文献

1
Diagnosis of pancreatic cancer. Serological markers.胰腺癌的诊断。血清学标志物。
Int J Pancreatol. 1991 Summer;9:93-8. doi: 10.1007/BF02925584.
2
Comparison of CA19-9 with other tumor markers in the diagnosis of cancer of the pancreas.CA19-9与其他肿瘤标志物在胰腺癌诊断中的比较。
Pancreas. 1994 Nov;9(6):720-4. doi: 10.1097/00006676-199411000-00008.
3
A clinical evaluation of various tumor markers for the diagnosis of pancreatic cancer.用于胰腺癌诊断的多种肿瘤标志物的临床评估。
Int J Pancreatol. 1990 Aug-Nov;7(1-3):25-36. doi: 10.1007/BF02924217.
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Novel serum tumor marker, RCAS1, in pancreatic diseases.新型血清肿瘤标志物RCAS1在胰腺疾病中的作用
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Behavior of tumor markers CA19.9, CA195, CAM43, CA242, and TPS in the diagnosis and follow-up of pancreatic cancer.肿瘤标志物CA19.9、CA195、CAM43、CA242和TPS在胰腺癌诊断及随访中的表现
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The possibility of diagnosing small pancreatic cancer (less than 4.0 cm) by measuring various serum tumor markers. A retrospective study.通过检测各种血清肿瘤标志物诊断小胰腺癌(小于4.0厘米)的可能性。一项回顾性研究。
Cancer. 1991 Jul 1;68(1):149-52. doi: 10.1002/1097-0142(19910701)68:1<149::aid-cncr2820680127>3.0.co;2-9.
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Comparing the diagnostic accuracy of five common tumour biomarkers and CA19-9 for pancreatic cancer: a protocol for a network meta-analysis of diagnostic test accuracy.比较五种常见肿瘤生物标志物和CA19-9对胰腺癌的诊断准确性:一项诊断试验准确性网络Meta分析的方案
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Various tumor markers for small pancreatic cancer with special reference to the present status of pancreatic cancer in Japan and our experience over the past 2 years.小胰腺癌的各种肿瘤标志物,特别提及日本胰腺癌的现状及我们过去两年的经验。
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Comparative study of CA242 and CA19-9 for the diagnosis of pancreatic cancer.CA242与CA19-9用于胰腺癌诊断的比较研究
Br J Cancer. 1994 Sep;70(3):481-6. doi: 10.1038/bjc.1994.331.

引用本文的文献

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Advances in biomarker research for pancreatic cancer.胰腺癌生物标志物研究进展。
Curr Pharm Des. 2012;18(17):2439-51. doi: 10.2174/13816128112092439.
2
Production of endothelin-1 and thrombomodulin by human pancreatic cancer cells.人胰腺癌细胞产生内皮素-1和血栓调节蛋白。
Br J Cancer. 1994 Jun;69(6):1059-64. doi: 10.1038/bjc.1994.208.

本文引用的文献

1
Radioimmunometric assay for a monoclonal antibody-defined tumor marker, CA 19-9.针对单克隆抗体定义的肿瘤标志物CA 19-9的放射免疫分析。
Clin Chem. 1983 Mar;29(3):549-52.
2
Relationship of carbohydrate antigen 19-9 and Lewis antigens in pancreatic cancer.胰腺癌中糖类抗原19-9与Lewis抗原的关系
Cancer Res. 1987 Oct 15;47(20):5501-3.
3
Evaluation of serum pancreatic enzymes, carbohydrate antigen 19-9, and carcinoembryonic antigen in various pancreatic diseases.多种胰腺疾病中血清胰酶、糖类抗原19-9及癌胚抗原的评估
Am J Gastroenterol. 1985 Aug;80(8):630-6.