Lu Shui-Ming, Alper Howard
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada.
Chemistry. 2007;13(20):5908-16. doi: 10.1002/chem.200601724.
Intramolecular cyclocarbonylation reactions with palladium-complexed dendrimers on silica gel as catalysts are very effective for the synthesis of twelve- to eighteen-membered ring macrocycles. This process can tolerate a wide variety of functional groups, including halide, ether, ketone, and ester. The heterogeneous dendritic catalysts facilitate excellent substrate reactivity, affording oxygen-, nitrogen-, or sulfur-containing tricyclic heterocycles in 70-92 % yields. Importantly, these systems are easily recovered by simple filtration and reused several times with only a slight loss of activity.
以硅胶负载钯络合树枝状聚合物为催化剂的分子内环羰基化反应，对于十二元至十八元环大环化合物的合成非常有效。该过程能够耐受多种官能团，包括卤化物、醚、酮和酯。多相树枝状催化剂具有优异的底物反应活性，能以70% - 92%的产率得到含氧、氮或硫的三环杂环化合物。重要的是，这些体系通过简单过滤即可轻松回收，并能重复使用多次，活性仅有轻微损失。
