串联钯催化加成/环羰基化反应：高效合成 2-杂喹唑啉-4(3H)-酮。
Tandem palladium-catalyzed addition/cyclocarbonylation: an efficient synthesis of 2-heteroquinazolin-4(3H)-ones.
机构信息
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5.
出版信息
Org Lett. 2010 Mar 19;12(6):1188-91. doi: 10.1021/ol902924x.
PMID:20184348
Abstract
A highly practical and efficient method for the synthesis of 2-heteroquinazolin-4(3H)-ones has been developed by a palladium-catalyzed tandem reaction. Under mild reaction conditions (80 degrees C, 100 psi), a wide variety of 2-heteroquinazolin-4(3H)-ones were obtained in good to excellent yields.
摘要
一种高效实用的 2-杂环喹唑啉-4(3H)-酮合成方法，通过钯催化的串联反应实现。在温和的反应条件（80 摄氏度，100 磅/平方英寸）下，多种 2-杂环喹唑啉-4(3H)-酮以良好至优秀的收率得到。
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