Lai S-W, Chang W-L, Peng C-Y, Liao K-F
Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan.
Intern Med J. 2007 Jul;37(7):472-7. doi: 10.1111/j.1445-5994.2007.01361.x. Epub 2007 Apr 16.
Few studies have focused on the clandestinely consumed amphetamine as a primary drug. The purpose of this study was to estimate the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and the related factors in male amphetamine-inhaling abusers.
This was a cross-sectional study. From November 2004 to February 2005, 285 amphetamine-inhaling male subjects at one prison in Taiwan and 285 age-matched healthy men without history of using illicit drugs or tattooing were enrolled. A face-to-face interview focusing on amphetamine-addicted history and sociodemographic information was used. Hepatitis B surface antigen (HBsAg) and anti-HCV were tested.
The mean age of the subjects was 34.1 +/- 8.6 years (range 17-75 years). Among 285 subjects, 13.3% were positive for HBsAg, 20.0% positive for anti-HCV and 2.5% positive for combined HBsAg and anti-HCV. Multivariate logistic regression analysis showed that tattoo (odds ratio (OR) 2.97, 95% confidence interval (CI) 1.37-6.43) and elevated alanine aminotransferase (ALT) (OR 3.15, 95% CI 1.49-6.66) were independently related to persons being anti-HCV positive. Elevated ALT was related to persons being HBsAg positive (OR 2.60, 95% CI 1.15-5.89).
Screening of HBV and HCV infection among amphetamine-inhaling abusers remains necessary. Tattoo and elevated ALT are identified as the related factors for being anti-HCV positive. Elevated ALT is the related factor for being HBsAg positive.
很少有研究关注将秘密吸食的苯丙胺作为主要毒品的情况。本研究的目的是估计男性苯丙胺吸食者中乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染的患病率及相关因素。
这是一项横断面研究。2004年11月至2005年2月，招募了台湾一所监狱中的285名吸食苯丙胺的男性受试者以及285名年龄匹配、无非法药物使用或纹身史的健康男性。采用面对面访谈，重点关注苯丙胺成瘾史和社会人口学信息。检测乙型肝炎表面抗原（HBsAg）和抗HCV。
受试者的平均年龄为34.1±8.6岁（范围17 - 75岁）。在285名受试者中，HBsAg阳性率为13.3%，抗HCV阳性率为20.0%，HBsAg和抗HCV合并阳性率为2.5%。多因素逻辑回归分析显示，纹身（比值比（OR）2.97，95%置信区间（CI）1.37 - 6.43）和丙氨酸转氨酶（ALT）升高（OR 3.15，95% CI 1.49 - 6.66）与抗HCV阳性独立相关。ALT升高与HBsAg阳性相关（OR 2.60，95% CI 1.15 - 5.89）。
对苯丙胺吸食者进行HBV和HCV感染筛查仍然必要。纹身和ALT升高被确定为抗HCV阳性的相关因素。ALT升高是HBsAg阳性的相关因素。
