Kaur G, Singh M, Mehra N K
Department of Transplant Immunology & Immunogenetics, All India Institute of Medical Sciences, New Delhi-110029, India.
Tissue Antigens. 2007 Apr;69 Suppl 1:243-4. doi: 10.1111/j.1399-0039.2006.773_5.x.
International collaborative efforts through histocompatibility workshops have helped greatly in collating useful data on interpopulation differences in genetic susceptibility to mycobacterial and viral infections. These are imperative in exploring the genetic basis of disease pathogenesis and host resistance. Because infectious diseases involve multigenic complex traits, several genetic variants contribute modifying effects on the disease but disease outcome depends on the net relative hazards of individual genetic loci taken together. Further because occurrence of genetic variants varies in a population-specific manner, it becomes even more complicated to show genetic influences across populations. For this, large study cohorts representing different ethnicities are needed. Information thus gained could lead to the development of more effective vaccine design to combat or diminish the emergence of pathogenic multidrug resistant forms.
通过组织相容性研讨会开展的国际合作努力，在整理关于人群间对分枝杆菌和病毒感染的遗传易感性差异的有用数据方面发挥了巨大作用。这些数据对于探索疾病发病机制和宿主抵抗力的遗传基础至关重要。由于传染病涉及多基因复杂性状，多个基因变异对疾病有修饰作用，但疾病结局取决于各个基因位点综合起来的净相对风险。此外，由于基因变异的发生在人群中具有特异性，要证明不同人群间的遗传影响就变得更加复杂。为此，需要有代表不同种族的大型研究队列。由此获得的信息可能会推动开发更有效的疫苗设计，以对抗或减少致病性多重耐药形式的出现。
