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第14届国际HLA与免疫遗传学研讨会:犬类主要组织相容性复合体(DLA)多样性联合研究报告

14th International HLA and Immunogenetics Workshop: report on joint study on canine DLA diversity.

作者信息

Kennedy L J

机构信息

Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK.

出版信息

Tissue Antigens. 2007 Apr;69 Suppl 1:269-71. doi: 10.1111/j.1399-0039.2006.00778.x.

Abstract

The canine DLA diversity component of the 14th International HLA and Immunogenetics (IHI) Workshop had three main aims: i) to establish the range of DLA class II (DRBI, DQA1, DQB1) diversity and their distribution in dog breeds, ii) to identify DLA class II haplotypes by segregation in families and iii) to examine DLA class II associations with disease susceptibility. Over 1600 dogs from seven participating laboratories were typed for three DLA class II loci as part of the workshop. Standard sequence-based typing methods were used, and all the data were of high quality.

摘要

第14届国际HLA与免疫遗传学(IHI)研讨会的犬类DLA多样性项目有三个主要目标:i)确定犬类II类DLA(DRBI、DQA1、DQB1)的多样性范围及其在犬种中的分布,ii)通过家系分离鉴定II类DLA单倍型,iii)研究II类DLA与疾病易感性的关联。作为研讨会的一部分,来自七个参与实验室的1600多只犬对三个II类DLA基因座进行了分型。使用了基于序列的标准分型方法,所有数据质量都很高。

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