Chen Ming-long, Yang Bing, Xu Dong-jie, Zou Jian-gang, Shan Qi-jun, Chen Chun, Chen Hong-wu, Li Wen-qi, Cao Ke-jiang
Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2007 Feb;35(2):119-22.
To report the electrophysiological findings and the ablation strategies in patients with atrial tachyarrhythmias (ATAs) or atrial fibrillation (AF) recurrence after left atrial circumferential ablation (LACA) in the treatment of AF.
91 patients with AF had LACA procedure from April 2004 to May 2006, 19 of which accepted the second ablation procedure due to ATAs or AF recurrence. In all the 19 patients [17 male, 2 female, age 25 - 65 (53 +/- 12) years], 11 presented with paroxysmal AF before the first ablation procedure, 2 with persistent AF and 6 with permanent AF. Pulmonary vein potentials (PVP) were investigated in both sides in all the patients.
Delayed PVP was identified inside the left circular line in 5 patients, in the right in 1 and both in 2 during sinus rhythm. "Gap" conduction was found and successfully closed guided by circular mapping catheter. In 3 cases, irregular left atrial tachycardia was caused by fibrillation rhythm inside the left ring via decremental "gap" conduction. Reisolation was done successfully again guided by 3-D mapping and made the left atrium in sinus rhythm but the fibrillation rhythm was still inside the left ring. Pulmonary vein tachycardia with 1:1 conduction to the left atrium presented in one case and reisolation stopped the tachycardia. No PVP was discovered in both sides in 4 patients but other tachycardias could be induced, including two right atrial scar related tachycardias, two supraventricular tachycardias mediated by concealed accessory pathway, one cavo-tricuspid isthmus dependent atrial flutter and one focal atrial tachycardia near the coronary sinus ostium. All the tachycardias in these 4 patients were successfully ablated with the help of routine and 3-D mapping techniques. In the rest 3, which were in AF rhythm, LACA was successfully done again. After a mean follow-up of 4 - 26 (11.5 +/- 8.5) months, 16 patients were symptom free without anti-arrhythmic drug therapy; 1 of them had frequent palpitation attack with Holter recording of atrial premature contractions; 2 of them with permanent AF became paroxysmal in one, and still in AF in the other.
Reconduction between the left atrium and the pulmonary veins is the dominant factor for post-LACA ATAs and AF recurrence. Other forms of atrial tachycardias or supraventricular tachycardias may coexist with AF or sometimes trigger AF. LACA can not sufficiently modify AF substrate in some permanent AF patients.
报告在房颤治疗中接受左心房环周消融(LACA)后出现房性快速心律失常(ATA)或房颤复发患者的电生理检查结果及消融策略。
2004年4月至2006年5月,91例房颤患者接受了LACA手术,其中19例因ATA或房颤复发接受了二次消融手术。在这19例患者中[17例男性,2例女性,年龄25 - 65(53±12)岁],11例在首次消融手术前表现为阵发性房颤,2例为持续性房颤,6例为永久性房颤。所有患者均对双侧肺静脉电位(PVP)进行了研究。
窦性心律时,5例患者在左环线内发现延迟PVP,1例在右侧发现,2例双侧均有。发现“缝隙”传导,并在环形标测导管引导下成功封闭。3例患者中,左环内的颤动节律通过递减性“缝隙”传导导致不规则左房性心动过速。在三维标测引导下再次成功进行了肺静脉隔离,使左房恢复窦性心律,但左环内仍为颤动节律。1例患者出现肺静脉性心动过速,1:1传导至左房,肺静脉隔离终止了心动过速。4例患者双侧均未发现PVP,但可诱发其他心动过速,包括2例与右房瘢痕相关的心动过速、2例由隐匿性旁路介导的室上性心动过速、1例三尖瓣峡部依赖性房扑和1例冠状窦口附近的局灶性房性心动过速。这4例患者的所有心动过速均在常规和三维标测技术辅助下成功消融。其余3例处于房颤节律的患者再次成功进行了LACA。平均随访4 - 26(11.5±8.5)个月后,16例患者无需抗心律失常药物治疗,无症状;其中1例患者有频繁心悸发作,动态心电图记录有房性早搏;2例永久性房颤患者中,1例转变为阵发性房颤,另1例仍为房颤。
左心房与肺静脉之间的再传导是LACA术后ATA和房颤复发的主要因素。其他形式的房性心动过速或室上性心动过速可能与房颤共存,或有时引发房颤。在一些永久性房颤患者中,LACA不能充分改变房颤基质。