Xie Li-Ping, Bai Yu, Zhang Xin-Zong, Zheng Xiang-Yi, Yao Kang-Shou, Xu Ling, Zeegers Maurice P
Department of Urology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Urology. 2007 Apr;69(4):680-4. doi: 10.1016/j.urology.2006.12.030.
To investigate the associations of prostate enlargement with obesity and hypertension in Chinese men.
A total of 649 men from Zhejiang, China were invited to the Family Planning Station of Wenlin to undergo prostate volume measurement with transrectal ultrasonography. Benign prostatic enlargement (BPE) has been defined as a prostate volume larger than 20 cm3. The associations between BPE and prostate volume with body mass index (BMI) and blood pressure were evaluated by multivariate linear and logistic regression analyses.
Overweight (BMI of 25 or more but less than 28 kg/m2) and obese (BMI of 28 kg/m2 or more) men experienced a significantly increased age-adjusted risk of BPE compared with men with a lower BMI (odds ratio 1.63, 95% confidence interval 1.16 to 2.30, and odds ratio 2.26, 95% confidence interval 1.11 to 4.59, respectively). Each 0.37-kg/m2 increase (95% confidence interval 0.18 to 0.57, P <0.01) in the BMI was associated with a 1-cm3 increase in prostate volume. No associations were observed between hypertension and BPE.
This is the first study to provide evidence that the BMI is positively associated with prostate volume in the Chinese population. Obese Chinese men are at increased risk of an enlarged prostate compared with nonobese Chinese men.
研究中国男性前列腺增生与肥胖及高血压之间的关联。
共邀请了649名来自中国浙江的男性到温岭计划生育站，通过经直肠超声检查测量前列腺体积。良性前列腺增生（BPE）定义为前列腺体积大于20立方厘米。通过多变量线性和逻辑回归分析评估BPE和前列腺体积与体重指数（BMI）及血压之间的关联。
与BMI较低的男性相比，超重（BMI为25或更高但低于28千克/平方米）和肥胖（BMI为28千克/平方米或更高）的男性经年龄调整后的BPE风险显著增加（优势比分别为1.63，95%置信区间为1.16至2.30；优势比为2.26，95%置信区间为1.11至4.59）。BMI每增加0.37千克/平方米（95%置信区间为0.18至0.57，P<0.01）与前列腺体积增加1立方厘米相关。未观察到高血压与BPE之间存在关联。
这是第一项提供证据表明BMI与中国人群前列腺体积呈正相关的研究。与非肥胖中国男性相比，肥胖中国男性前列腺增大的风险增加。
