Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.
J Endocrinol Invest. 2011 Nov;34(10):e336-42. doi: 10.3275/7855. Epub 2011 Jul 7.
Obesity is associated with a systemic, low-grade inflammatory state. Although the relationship between obesity and semen parameters or prostate diseases has been previously investigated, the association between body mass index (BMI), prostate inflammatory diseases and color- Doppler ultrasound (CDU) of the male genital tract (MGT) has been poorly studied.
To evaluate the association between BMI and CDU features of the MGT, signs and symptoms of prostate inflammation, semen parameters.
MATERIALS/SUBJECTS AND METHODS: We studied 222 men seeking medical care for couple infertility. According to the World Health Organization classification, subjects were divided into 3 groups: normal weight (no.=131, BMI=18.5-24.9 kg/m2), overweight (no.=71, BMI=25.0-29.9 kg/m2), obese (no.=20, BMI≥30.0 kg/m2). All patients underwent simultaneous testosterone evaluation and seminal analysis, including interleukin 8 (sIL-8), along with scrotal and transrectal CDU, before and after ejaculation. Prostatitis symptoms were evaluated by National Institutes of Health- Chronic Prostatitis Symptom Index questionnaire.
After adjusting for age and testosterone levels, higher BMI was significantly related to higher prostate volume and several CDU features of the prostate, including macro-calcifications, inhomogeneity, higher arterial peak systolic velocity (the latter adjusted also for blood pressure), but not with abnormalities of testis, epididymis, seminal vesicles. Furthermore, higher BMI and BMI class were significantly related to higher sIL-8, a reliable surrogate marker of prostate inflammatory diseases, even after adjustment for age. Conversely, no associations among BMI, clinical symptoms of prostatitis or semen parameters were observed.
Subjects with higher BMI might develop CDU and biochemical signs suggestive of prostate inflammation, although not clinically overt.
肥胖与全身性低度炎症状态有关。尽管肥胖与精液参数或前列腺疾病之间的关系已被先前研究过，但体重指数（BMI）、前列腺炎症疾病与男性生殖系统（MGT）的彩色多普勒超声（CDU）之间的关系尚未得到充分研究。
评估 BMI 与 MGT 的 CDU 特征、前列腺炎症的迹象和症状、精液参数之间的相关性。
材料/受试者和方法：我们研究了 222 名因夫妻不孕而寻求医疗的男性。根据世界卫生组织的分类，受试者分为 3 组：正常体重（无=131，BMI=18.5-24.9kg/m2）、超重（无=71，BMI=25.0-29.9kg/m2）、肥胖（无=20，BMI≥30.0kg/m2）。所有患者在射精前和射精后同时进行睾酮评估和精液分析，包括白细胞介素 8（sIL-8），以及阴囊和经直肠 CDU。前列腺炎症状通过美国国立卫生研究院-慢性前列腺炎症状指数问卷进行评估。
在调整年龄和睾酮水平后，较高的 BMI 与前列腺体积较大以及前列腺的几种 CDU 特征显著相关，包括大钙化、不均匀性、较高的动脉收缩期峰值速度（后者也针对血压进行了调整），但与睾丸、附睾、精囊的异常无关。此外，较高的 BMI 和 BMI 类别与较高的 sIL-8 显著相关，sIL-8 是前列腺炎症的可靠替代标志物，即使在调整年龄后也是如此。相反，在 BMI、前列腺炎的临床症状或精液参数之间没有观察到相关性。
尽管没有明显的临床症状，但较高 BMI 的受试者可能会出现 CDU 和生化迹象表明存在前列腺炎症。
