Jicha D L, Mulé J J, Rosenberg S A
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
J Exp Med. 1991 Dec 1;174(6):1511-5. doi: 10.1084/jem.174.6.1511.
Interleukin 7 (IL-7) is a 25-kD cytokine that was initially described as a pre-B cell growth factor. This cytokine has also been shown to have T cell proliferative and differentiation effects. In this report, we demonstrate that antitumor cytotoxic T lymphocytes (CTL) generated by secondary in vitro sensitization of draining lymph node cells in IL-7 are effective in treating 3-day syngeneic methylcholanthrene (MCA) sarcoma pulmonary metastases in mice. In vivo titrations comparing IL-7 to IL-2 antitumor CTL show that they have equivalent potency in adoptive immunotherapy. IL-7 antitumor CTL generated against MCA sarcomas of weak immunogeneity are also tumor specific in their in vivo efficacy. This study represents the first successful use of a cytokine other than IL-2 for the generation of cells with in vivo efficacy in cellular adoptive transfer.
白细胞介素7（IL-7）是一种25千道尔顿的细胞因子，最初被描述为前B细胞生长因子。这种细胞因子也已被证明具有T细胞增殖和分化作用。在本报告中，我们证明，通过在IL-7中对引流淋巴结细胞进行二次体外致敏产生的抗肿瘤细胞毒性T淋巴细胞（CTL）可有效治疗小鼠3日龄同基因甲基胆蒽（MCA）肉瘤肺转移。将IL-7与IL-2抗肿瘤CTL进行体内滴定比较表明，它们在过继免疫治疗中具有同等效力。针对免疫原性较弱的MCA肉瘤产生的IL-7抗肿瘤CTL在体内疗效上也具有肿瘤特异性。本研究代表了首次成功使用IL-2以外的细胞因子来产生在细胞过继转移中具有体内疗效的细胞。
