白细胞介素4（B细胞刺激因子1）可介导针对新鲜肿瘤细胞的淋巴因子激活的杀伤细胞活性的诱导。
Interleukin 4 (B cell stimulatory factor 1) can mediate the induction of lymphokine-activated killer cell activity directed against fresh tumor cells.
作者信息
Mulé J J, Smith C A, Rosenberg S A
出版信息
J Exp Med. 1987 Sep 1;166(3):792-7. doi: 10.1084/jem.166.3.792.
Abstract
Interleukin 4 (IL-4) expresses multiple biologic activities, including B cell, mast cell, and T cell stimulation. We showed that the incubation of resting splenocytes from C57BL/6 mice solely in purified native or recombinant mouse IL-4 results in the generation of lymphokine-activated killer (LAK) activity directed against fresh, syngeneic sarcoma cells. The precursor activated by IL-4 expresses surface asialo-GM1. In addition, IL-4 is capable of amplifying the splenic LAK activity induced by recombinant IL-2. The generation, by IL-4, of killer cells with broad antitumor reactivity raises the possibility of using IL-4 alone or in combination with IL-2 in the immunotherapy of cancer in animal models.
摘要
白细胞介素4（IL-4）具有多种生物学活性，包括刺激B细胞、肥大细胞和T细胞。我们发现，将C57BL/6小鼠的静止脾细胞仅在纯化的天然或重组小鼠IL-4中孵育，会产生针对新鲜同基因肉瘤细胞的淋巴因子激活的杀伤（LAK）活性。被IL-4激活的前体细胞表达表面去唾液酸GM1。此外，IL-4能够增强重组IL-2诱导的脾脏LAK活性。IL-4产生具有广泛抗肿瘤反应性的杀伤细胞，这增加了在动物模型癌症免疫治疗中单独使用IL-4或与IL-2联合使用的可能性。
相似文献
1
Interleukin 4 (B cell stimulatory factor 1) can mediate the induction of lymphokine-activated killer cell activity directed against fresh tumor cells.白细胞介素4（B细胞刺激因子1）可介导针对新鲜肿瘤细胞的淋巴因子激活的杀伤细胞活性的诱导。
J Exp Med. 1987 Sep 1;166(3):792-7. doi: 10.1084/jem.166.3.792.
2
Combined therapy of mice bearing a lymphokine-activated killer-resistant tumor with recombinant interleukin 2 and an antitumor monoclonal antibody capable of inducing antibody-dependent cellular cytotoxicity.用重组白细胞介素2和一种能够诱导抗体依赖性细胞毒性的抗肿瘤单克隆抗体对携带抗淋巴因子激活的杀伤细胞肿瘤的小鼠进行联合治疗。
Cancer Res. 1988 Mar 1;48(5):1173-9.
3
4
5
The anti-tumor efficacy of lymphokine-activated killer cells and recombinant interleukin 2 in vivo: direct correlation between reduction of established metastases and cytolytic activity of lymphokine-activated killer cells.淋巴因子激活的杀伤细胞和重组白细胞介素2在体内的抗肿瘤疗效：已形成转移灶的减少与淋巴因子激活的杀伤细胞的细胞溶解活性之间的直接相关性。
J Immunol. 1986 May 15;136(10):3899-909.
6
7
8
9
Interleukin 5 enhances interleukin 2-mediated lymphokine-activated killer activity.白细胞介素5增强白细胞介素2介导的淋巴因子激活的杀伤细胞活性。
J Exp Med. 1989 Aug 1;170(2):583-8. doi: 10.1084/jem.170.2.583.
10
Generation of activated killer cells in tumor-bearing hosts.荷瘤宿主中活化杀伤细胞的产生。
Int J Cancer. 1987 Feb 15;39(2):232-9. doi: 10.1002/ijc.2910390218.
引用本文的文献
1
Induction of anti-tumour lymphocytes in cancer patients after brief exposure to supernatants from cultures of anti-CD3-stimulated allogeneic lymphocytes.癌症患者在短暂接触抗CD3刺激的同种异体淋巴细胞培养上清液后诱导抗肿瘤淋巴细胞。
Br J Cancer. 1997;76(8):1072-80. doi: 10.1038/bjc.1997.510.
2
Clonal and functional analysis for the augmentation of tumour-infiltrating lymphocytes by interleukin 4.白细胞介素4增强肿瘤浸润淋巴细胞的克隆及功能分析
Br J Cancer. 1996 Oct;74(7):1085-9. doi: 10.1038/bjc.1996.494.
3
In vitro and in vivo growth of B16F10 melanoma cells transfected with interleukin-4 cDNA and gene therapy with the transfectant.用白细胞介素-4 cDNA转染的B16F10黑色素瘤细胞的体外和体内生长以及用转染剂进行基因治疗。
J Cancer Res Clin Oncol. 1994;120(11):631-5. doi: 10.1007/BF01245372.
4
Cytokine-mediated gene therapy for cancer.细胞因子介导的癌症基因治疗。
Ann Surg Oncol. 1994 Sep;1(5):436-50. doi: 10.1007/BF02303818.
5
Human recombinant IL-4 decreases the emergence of non-specific cytolytic cells and favours the appearance of memory cells (CD4+CD45RO+) in the IL-2-driven development of cytotoxic T lymphocytes against autologous ovarian tumour cells.在白细胞介素-2驱动的针对自体卵巢肿瘤细胞的细胞毒性T淋巴细胞发育过程中，人重组白细胞介素-4减少了非特异性细胞溶解细胞的出现，并有利于记忆细胞（CD4+CD45RO+）的出现。
Clin Exp Immunol. 1995 Aug;101(2):362-8. doi: 10.1111/j.1365-2249.1995.tb08365.x.
6
Interleukin-3 and interleukin-4 each strongly inhibit the induction and function of human LAK cells.白细胞介素-3和白细胞介素-4均强烈抑制人淋巴因子激活的杀伤细胞（LAK细胞）的诱导及功能。
Clin Exp Immunol. 1988 Nov;74(2):166-70.
7
Human recombinant IL-4 suppresses the induction of human IL-2 induced lymphokine activated killer (LAK) activity.人重组白细胞介素-4抑制人白细胞介素-2诱导的淋巴因子激活的杀伤细胞（LAK）活性的诱导。
Clin Exp Immunol. 1988 Nov;74(2):162-5.
8
Interleukin 4 promotes the growth of tumor-infiltrating lymphocytes cytotoxic for human autologous melanoma.白细胞介素4促进对人自体黑色素瘤具有细胞毒性的肿瘤浸润淋巴细胞的生长。
J Exp Med. 1988 Dec 1;168(6):2183-91. doi: 10.1084/jem.168.6.2183.
9
Medullasin induces activated killer cells from human lymphocytes.髓拉辛可从人淋巴细胞诱导活化杀伤细胞。
Jpn J Cancer Res. 1988 Jun;79(6):687-90. doi: 10.1111/j.1349-7006.1988.tb02223.x.
10
Interleukin 5 enhances interleukin 2-mediated lymphokine-activated killer activity.白细胞介素5增强白细胞介素2介导的淋巴因子激活的杀伤细胞活性。
J Exp Med. 1989 Aug 1;170(2):583-8. doi: 10.1084/jem.170.2.583.
本文引用的文献
1
Interleukin 2 dependence of human natural killer (NK) cell activity.人自然杀伤（NK）细胞活性对白细胞介素2的依赖性。
J Immunol. 1983 Apr;130(4):1970-3.
2
3
Interleukin 2.白细胞介素2
Annu Rev Immunol. 1984;2:319-33. doi: 10.1146/annurev.iy.02.040184.001535.
4
Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor.静止B细胞上Ia抗原表达增加：B细胞生长因子的另一作用
Proc Natl Acad Sci U S A. 1984 Oct;81(19):6149-53. doi: 10.1073/pnas.81.19.6149.
5
Interleukin-induced increase in Ia expression by normal mouse B cells.白细胞介素诱导正常小鼠B细胞Ia表达增加。
J Exp Med. 1984 Sep 1;160(3):679-94. doi: 10.1084/jem.160.3.679.
6
Biological activity of recombinant human interleukin-2 produced in Escherichia coli.在大肠杆菌中产生的重组人白细胞介素-2的生物活性。
Science. 1984 Mar 30;223(4643):1412-4. doi: 10.1126/science.6367046.
7
Adoptive immunotherapy of established pulmonary metastases with LAK cells and recombinant interleukin-2.采用LAK细胞和重组白细胞介素-2对已形成的肺转移瘤进行过继性免疫治疗。
Science. 1984 Sep 28;225(4669):1487-9. doi: 10.1126/science.6332379.
8
Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1.B细胞刺激因子1与IgG1的B细胞分化因子的血清学、生化及功能特性
J Exp Med. 1985 Nov 1;162(5):1726-31. doi: 10.1084/jem.162.5.1726.
9
Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities.一种表达B细胞刺激因子1活性以及T细胞和肥大细胞刺激活性的小鼠白细胞介素cDNA克隆的分离与鉴定。
Proc Natl Acad Sci U S A. 1986 Apr;83(7):2061-5. doi: 10.1073/pnas.83.7.2061.
10
Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.一种与小鼠B细胞刺激因子1同源的人白细胞介素cDNA克隆的分离与鉴定，该克隆表达B细胞和T细胞刺激活性。
Proc Natl Acad Sci U S A. 1986 Aug;83(16):5894-8. doi: 10.1073/pnas.83.16.5894.
Zotero 插件