Grünbacher Gerda, Weger Wolfgang, Marx-Neuhold Ernestine, Pilger Ernst, Köppel Herwig, Wascher Thomas, März Winfried, Renner Wilfried
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, 8036 Graz Austria.
Thromb Res. 2007;121(1):33-6. doi: 10.1016/j.thromres.2007.03.007. Epub 2007 Apr 19.
Thrombin-induced conversion of fibrinogen to fibrin plays an essential role in hemostasis and results in the stabilization of thrombi. Elevated plasma fibrinogen levels have been associated with both increased plasma viscosity and platelet aggregability. Recently, a haplotype-tagging single nucleotide polymorphism characterized by a C to T substitution at nucleotide 10034 of the fibrinogen gamma gene (FGG 10034C>T, rs2066865), has been proposed as a novel risk factor for deep venous thrombosis (DVT). Aim of the present study was to provide further data on the role of the FGG 10034C>T polymorphism for DVT.
FGG genotypes were determined by 5'-exonuclease assay (TaqMan) in 358 patients with documented DVT and a total of 783 control subjects.
In a multivariate analysis adjusting for age, sex, presence of factor V Leiden and carriage of prothrombin 20210A, homozygosity for the FGG 10034 TT genotype yielded an odds ratio of 2.01 (95% CI 1.23-3.31; p=0.006) for DVT.
Our data confirm the primary finding that the FGG 10034C>T polymorphism is associated with DVT risk.
凝血酶诱导纤维蛋白原转化为纤维蛋白在止血过程中起关键作用，并导致血栓稳定。血浆纤维蛋白原水平升高与血浆粘度增加和血小板聚集性增强均相关。最近，一种以纤维蛋白原γ基因第10034位核苷酸由C替换为T为特征的单倍型标签单核苷酸多态性（FGG 10034C>T，rs2066865），已被提出作为深静脉血栓形成（DVT）的一种新的危险因素。本研究的目的是提供关于FGG 10034C>T多态性在DVT中作用的更多数据。
采用5'-核酸外切酶分析（TaqMan）法对358例有记录的DVT患者和总共783例对照受试者进行FGG基因分型。
在对年龄、性别、因子V莱顿的存在情况和凝血酶原20210A携带情况进行校正的多变量分析中，FGG 10034 TT基因型纯合子发生DVT的比值比为2.01（95%可信区间1.23 - 3.31；p = 0.006）。
我们的数据证实了主要发现，即FGG 10034C>T多态性与DVT风险相关。
