2,3,5-Substituted tetrahydrofurans as cancer chemopreventives. Part 1: synthesis and anti-cancer activities of 5-hydroxymethyl-2,3-diaryl-tetrahydro-furan-3-ols.
作者信息
Singh Palwinder, Mittal Anu, Kumar Subodh
机构信息
Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India.
出版信息
Bioorg Med Chem. 2007 Jun 15;15(12):3990-6. doi: 10.1016/j.bmc.2007.04.004. Epub 2007 Apr 6.
PMID:17446077
Abstract
The allylation of appropriate benzoin in presence of indium metal followed by m-CPBA mediated cyclization gave 5-hydroxymethyl-2,3-diaryl-tetrahydro-furan-3-ols. Investigations on 59 human tumor cell lines of these compounds identify four compounds exhibiting significant growth inhibition of tumor cells at particular cell lines. Compound 12 is very specific toward CCRF-CEM and SR cell lines of leukemia.
摘要
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