Crane Frederick L
Department of Biological Science, Purdue University, W. Lafayette, IN, USA.
Mitochondrion. 2007 Jun;7 Suppl:S2-7. doi: 10.1016/j.mito.2007.02.011. Epub 2007 Mar 16.
Details of the discovery of ubiquinone (coenzyme Q) are described in the context of research on mitochondria in the early 1950s. The importance of the research environment created by David E. Green to the recognition of the compound and its role in mitochondria is emphasized as well as the dedicated work of Karl Folkers to find the medical and nutritional significance. The development of diverse functions of the quinone from electron carrier and proton carrier in mitochondria to proton transport in other membranes and uncoupling protein control as well as antioxidant and prooxidant functions is introduced. The successful application in medicine points the way for future development.
泛醌（辅酶Q）的发现细节是在20世纪50年代初对线粒体的研究背景下进行描述的。文中强调了大卫·E·格林所营造的研究环境对认识该化合物及其在线粒体中的作用的重要性，以及卡尔·福克尔斯为探寻其医学和营养意义所做的专注工作。文中还介绍了醌从线粒体中的电子载体和质子载体到其他膜中的质子运输以及解偶联蛋白调控等多种功能的发展，以及其抗氧化和促氧化功能。在医学上的成功应用为未来发展指明了方向。
