Kurnellas Michael P, Lee Amanda K, Szczepanowski Karolynn, Elkabes Stella
Department of Neurology and Neuroscience, MSB, H-506, New Jersey Medical School-UMDNJ, 185 South Orange Ave, Newark, NJ 07103, USA.
Ann N Y Acad Sci. 2007 Mar;1099:287-91. doi: 10.1196/annals.1387.025.
The distinct role of plasma membrane calcium ATPase 2 (PMCA2) in the function of different neuronal subpopulations in the central nervous system is not well understood. We found that lack of PMCA2 leads to a reduction in the number of motor neurons in the spinal cord of PMCA2-null mice and to abnormal changes in molecular pathways in Purkinje cells. Thus, PMCA2 may have unique, nonredundant functions in spinal cord and cerebellar neurons. Our results suggest that anomalous alterations in PMCA2 activity or expression may induce pathology in some neuronal populations, a possibility that will be the focus of future investigations.
质膜钙ATP酶2（PMCA2）在中枢神经系统不同神经元亚群功能中的独特作用尚未得到充分了解。我们发现，PMCA2的缺失导致PMCA2基因敲除小鼠脊髓中运动神经元数量减少，并导致浦肯野细胞分子途径发生异常变化。因此，PMCA2可能在脊髓和小脑神经元中具有独特的、非冗余的功能。我们的结果表明，PMCA2活性或表达的异常改变可能在某些神经元群体中诱发病变，这一可能性将是未来研究的重点。
