Role of plasma membrane calcium ATPase isoform 2 in neuronal function in the cerebellum and spinal cord.

The distinct role of plasma membrane calcium ATPase 2 (PMCA2) in the function of different neuronal subpopulations in the central nervous system is not well understood. We found that lack of PMCA2 leads to a reduction in the number of motor neurons in the spinal cord of PMCA2-null mice and to abnormal changes in molecular pathways in Purkinje cells. Thus, PMCA2 may have unique, nonredundant functions in spinal cord and cerebellar neurons. Our results suggest that anomalous alterations in PMCA2 activity or expression may induce pathology in some neuronal populations, a possibility that will be the focus of future investigations.