Murthy Ravi, Brown Daniel B, Salem Riad, Meranze Steven G, Coldwell Douglas M, Krishnan Sunil, Nunez Rodolfo, Habbu Amit, Liu David, Ross William, Cohen Alan M, Censullo Michael
Division of Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
J Vasc Interv Radiol. 2007 Apr;18(4):553-61; quiz 562. doi: 10.1016/j.jvir.2007.02.002.
Hepatic arterial therapy with yttrium-90 microspheres exploits the avenue provided by the neoplastic microvasculature to deliver high-energy, low-penetrating therapeutic doses of radiation. Variant hepatic arterial anatomy, collateral vessels, and changes in flow dynamics during treatment can affect particle dispersion and lead to nontarget particle distribution and subsequent gastrointestinal morbidity. Awareness of these variances and techniques to prevent gastrointestinal tract microsphere delivery is essential in mitigating this serious complication. Our aim is to increase the understanding of the role of various imaging and preventative techniques in minimizing this undesired effect.
钇-90微球肝动脉治疗利用肿瘤微血管提供的途径来输送高能量、低穿透性的治疗剂量辐射。肝动脉解剖变异、侧支血管以及治疗期间血流动力学的变化会影响粒子分散，并导致非靶粒子分布以及随后的胃肠道并发症。了解这些变异以及预防胃肠道微球输送的技术对于减轻这一严重并发症至关重要。我们的目的是增进对各种成像和预防技术在最小化这种不良影响方面作用的理解。
