Jicha G A, Salamone J D
Department of Psychology, University of Connecticut, Storrs 06269-1020.
J Neurosci. 1991 Dec;11(12):3822-9. doi: 10.1523/JNEUROSCI.11-12-03822.1991.
A series of experiments examined the effects of regional dopamine depletions produced by intrastriatal injections of 6-hydroxydopamine on voluntary and involuntary movements in rats. Depletion of dopamine in the ventrolateral striatum produced a substantial decrease in food intake, from which the animals recovered. Rats with dopamine depletions in anteroventromedial or dorsolateral striatum did not have significant feeding deficits. Rats with ventrolateral dopamine depletions showed no deficits in locomotor activity or rearing behavior; however, depletions of dopamine in dorsolateral striatum significantly reduced rearing. Vacuous jaw movements that resemble chewing were produced by dopamine depletion in the ventrolateral striatum, but not the anteroventromedial or dorsolateral striatum. Systemic administration of haloperidol (0.4 mg/kg) increased vacuous chewing responses in dopamine-depleted and control rats. Thus, vacuous chewing responses can result from reduced functional activity of striatal dopamine, and these responses share some characteristics with human parkinsonian symptoms. In addition, these data support the notion that the neostriatum is functionally heterogeneous and that the ventrolateral region is particularly important for oral motor control.
一系列实验研究了纹状体内注射6-羟基多巴胺所导致的局部多巴胺耗竭对大鼠自主运动和非自主运动的影响。腹外侧纹状体中的多巴胺耗竭导致食物摄入量大幅下降，不过动物随后恢复了。在前腹内侧或背外侧纹状体中多巴胺耗竭的大鼠没有明显的进食缺陷。腹外侧多巴胺耗竭的大鼠在运动活动或竖毛行为方面没有缺陷；然而，背外侧纹状体中的多巴胺耗竭显著减少了竖毛行为。腹外侧纹状体中的多巴胺耗竭会产生类似咀嚼的空嚼运动，而在前腹内侧或背外侧纹状体中则不会。全身性给予氟哌啶醇（0.4毫克/千克）会增加多巴胺耗竭大鼠和对照大鼠的空嚼反应。因此，空嚼反应可能是由于纹状体多巴胺功能活动降低所致，并且这些反应与人类帕金森症状有一些共同特征。此外，这些数据支持这样一种观点，即新纹状体在功能上是异质的，并且腹外侧区域对口腔运动控制尤为重要。
