Salamone J D, Johnson C J, McCullough L D, Steinpreis R E
Department of Psychology, University of Connecticut, Storrs 06269-1020.
Psychopharmacology (Berl). 1990;102(4):529-34. doi: 10.1007/BF02247136.
These experiments were undertaken to determine if local injection of pilocarpine in the neostriatum of the rat produces oral motor activities that are similar to those produced by systemic administration. In the first experiment, IP administration of 2.0-8.0 mg/kg pilocarpine increased chewing movements and tongue protrusions. In the second experiment, chronic guide cannulae were implanted bilaterally in ventromedial or ventrolateral striatum, and rats were injected with saline, 30, and 60 micrograms pilocarpine (per side). A dose-related increase in vacuous chewing was induced by injections of pilocarpine in the ventrolateral but not the ventromedial striatum. Tongue protrusions were induced by injections of pilocarpine into the ventromedial and the ventrolateral striatum. A third experiment demonstrated that this response was blocked completely by 10 micrograms scopolamine co-administered via the same cannulae, but the response was not reduced significantly by 10 micrograms haloperidol. These results indicate that ventrolateral striatal cholinergic mechanisms are involved in oral motor activities in the rat. This syndrome may provide a model for human clinical phenomena such as parkinsonian tremor.
进行这些实验是为了确定在大鼠新纹状体内局部注射毛果芸香碱是否会产生与全身给药相似的口腔运动活动。在第一个实验中，腹腔注射2.0 - 8.0毫克/千克的毛果芸香碱会增加咀嚼运动和伸舌动作。在第二个实验中，将慢性引导套管双侧植入腹内侧或腹外侧纹状体，给大鼠注射生理盐水、30微克和60微克毛果芸香碱（每侧）。在腹外侧而非腹内侧纹状体注射毛果芸香碱会引起与剂量相关的空嚼增加。向腹内侧和腹外侧纹状体注射毛果芸香碱会引起伸舌动作。第三个实验表明，通过同一套管共同注射10微克东莨菪碱可完全阻断这种反应，但10微克氟哌啶醇不会使反应显著降低。这些结果表明，腹外侧纹状体胆碱能机制参与了大鼠的口腔运动活动。这种综合征可能为帕金森震颤等人类临床现象提供一个模型。
