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小细胞肺癌预防性颅脑照射后发生意外性痴呆：病例报告

Unexpected dementia following prophylactic cranial irradiation for small cell lung cancer: case report.

作者信息

D'Ambrosio David J, Cohen Roger B, Glass Jon, Konski Andre, Buyyounouski Mark K, Feigenberg Steven J

机构信息

Department of Radiation Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

出版信息

J Neurooncol. 2007 Oct;85(1):77-9. doi: 10.1007/s11060-007-9384-5. Epub 2007 Apr 20.

DOI:10.1007/s11060-007-9384-5
PMID:17447010
Abstract

OBJECT

Prophylactic cranial irradiation (PCI) is commonly offered to patients with limited stage primary small cell lung cancer following a complete response.

METHODS

We present the unique case of a 76-year-old woman treated with PCI with a dose of 30 Gy in 15 fractions, at 200 cGy per fraction who developed progressive dementia.

CONCLUSIONS

This is the first reported case of dementia from PCI at this low dose per fraction. Patients need to be counseled regarding the risks and benefits of treatment, including dementia with treatment and risk of sequelae from CNS metastasis without treatment. The authors review the data supporting PCI and the incidence of radiation associated dementia.

摘要

目的

对于局限期原发性小细胞肺癌患者，在完全缓解后通常会给予预防性颅脑照射（PCI）。

方法

我们报告了一例独特的病例，一名76岁女性接受了PCI治疗，剂量为30 Gy，分15次，每次200 cGy，之后出现了进行性痴呆。

结论

这是首例关于如此低分次剂量PCI导致痴呆的报道病例。需要就治疗的风险和益处向患者提供咨询，包括治疗导致的痴呆以及不治疗发生中枢神经系统转移后遗症的风险。作者回顾了支持PCI的数据以及放射性痴呆的发生率。

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在同步接受顺铂和依托泊苷治疗的局限期小细胞肺癌中，每日两次胸部放疗与每日一次胸部放疗的比较。
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