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Promoter polymorphisms of UCP1, UCP2, and UCP3 are not associated with diabetic microvascular complications in type 2 diabetes.

作者信息

Rudofsky G, Schrödter A, Voron'ko O E, Schlotterer A, Humpert P M, Tafel J, Nawroth P P, Bierhaus A, Hamann A

机构信息

Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Heidelberg, Germany.

出版信息

Horm Metab Res. 2007 Apr;39(4):306-9. doi: 10.1055/s-2007-973816.

DOI:10.1055/s-2007-973816
PMID:17447170
Abstract
摘要

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Promoter polymorphisms of UCP1, UCP2, and UCP3 are not associated with diabetic microvascular complications in type 2 diabetes.解偶联蛋白1、解偶联蛋白2和解偶联蛋白3的启动子多态性与2型糖尿病的糖尿病微血管并发症无关。
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2
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3
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Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes.UCP2和UCP3的功能多态性与1型糖尿病患者糖尿病神经病变患病率降低相关。
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Associations between polymorphisms in the mitochondrial uncoupling proteins (UCPs) with T2DM.线粒体解偶联蛋白（UCPs）基因多态性与2型糖尿病之间的关联。
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Population genetic analysis of the uncoupling proteins supports a role for UCP3 in human cold resistance.人群遗传分析解偶联蛋白支持 UCP3 在人类抗寒中的作用。
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The common -55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipoprotein cholesterol levels in the general Japanese population.解偶联蛋白3基因启动子区域常见的-55C/T多态性降低了日本普通人群肥胖症的患病率，并提高了血清高密度脂蛋白胆固醇水平。
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引用本文的文献

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Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic health.解偶联蛋白 1 基因多态性的流行及其与心血管和代谢健康的关系。
PLoS One. 2022 Apr 28;17(4):e0266386. doi: 10.1371/journal.pone.0266386. eCollection 2022.
2
Association of UCP1 and UCP2 variants with diabetic retinopathy susceptibility in type-2 diabetes mellitus patients: a meta-analysis.UCP1 和 UCP2 变异与 2 型糖尿病患者糖尿病视网膜病变易感性的关联：一项荟萃分析。
BMC Ophthalmol. 2021 Feb 12;21(1):81. doi: 10.1186/s12886-021-01838-1.
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Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases.
解偶联蛋白（UCP）基因多态性与心脏代谢疾病的关系。
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-866G/A and Ins/Del polymorphisms in the UCP2 gene and diabetic kidney disease: case-control study and meta-analysis.UCP2基因中的-866G/A和Ins/Del多态性与糖尿病肾病：病例对照研究和荟萃分析
Genet Mol Biol. 2020 Mar 27;43(2):e20180374. doi: 10.1590/1678-4685-GMB-2018-0374. eCollection 2020.
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The A allele of the UCP2 -866G/A polymorphism changes UCP2 promoter activity in HUVECs treated with high glucose.UCP2-866G/A 多态性的 A 等位基因改变了高糖处理的 HUVECs 中 UCP2 启动子的活性。
Mol Biol Rep. 2019 Oct;46(5):4735-4741. doi: 10.1007/s11033-019-04918-0. Epub 2019 Jun 19.
6
Polymorphisms of the UCP2 Gene Are Associated with Glomerular Filtration Rate in Type 2 Diabetic Patients and with Decreased UCP2 Gene Expression in Human Kidney.UCP2基因多态性与2型糖尿病患者的肾小球滤过率相关，并与人肾中UCP2基因表达降低有关。
PLoS One. 2015 Jul 28;10(7):e0132938. doi: 10.1371/journal.pone.0132938. eCollection 2015.
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PLoS One. 2014 Nov 14;9(11):e112670. doi: 10.1371/journal.pone.0112670. eCollection 2014.
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Genetic Variance in Uncoupling Protein 2 in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional -866G>A Promoter Variant (rs659366).解偶联蛋白2的基因变异与肥胖、2型糖尿病及相关代谢性状的关系：聚焦功能性-866G>A启动子变异（rs659366）
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