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[甲基对硫磷和代森锌给药对大鼠某些肝脏酶活性的影响]

[Effect of methyl parathion and zineb administration on the activity of some hepatic enzymes in rats].

作者信息

Albrecht R, Pélissier M A, Manchon P, Dupuis D

出版信息

Ann Nutr Aliment. 1975;29(3):223-38.

PMID:174473
Abstract

Male albinos rats were fed diets containing parathion-methyl or Zineb so that the average daily intake is 1/10 or 1/20 lethal dose 50, for a period of 4 or 8 weeks. The activity of hepatic microsomal enzymes, namely :aminopyrine N-demethylase, BHT oxidase, aniline hydroxylase, Butter Yellow & Amaranth reductases, NADPH-cyt. c reductase, G6P phosphatase, were measured. The activities of G6P & 6PG deshydrogenases were also determined. With the application of the parathion-methyl doses, the only effect showed is the lowering of the microsomal protein concentration.

摘要

给雄性白化病大鼠喂食含有甲基对硫磷或代森锌的饲料,使其平均每日摄入量为半数致死剂量的1/10或1/20,持续4周或8周。测定了肝微粒体酶的活性,即:氨基比林N-脱甲基酶、丁基羟基甲苯氧化酶、苯胺羟化酶、奶油黄和苋菜红还原酶、NADPH-细胞色素c还原酶、葡萄糖-6-磷酸酶。还测定了葡萄糖-6-磷酸和6-磷酸葡萄糖脱氢酶的活性。使用甲基对硫磷剂量后,唯一显示出的影响是微粒体蛋白浓度降低。

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