Brandt-Rauf P W
Department of Medicine, Columbia University, New York, NY 10032.
J Occup Med. 1991 Sep;33(9):951-5.
Pulmonary carcinogenesis due to occupational and environmental exposures to chemical carcinogens such as polycyclic aromatic hydrocarbons presents an interesting model for study of possible oncogene-related cancer biomarkers. Polycyclic aromatic hydrocarbons are important respiratory carcinogens and have been shown to cause specific mutational lesions that can lead to the activation of the ras oncogene and expression of its p21 protein product; ras oncogene activation and p21 expression frequently are detected in human lung cancers. In addition, the p21 protein is detectable via immunoblotting techniques in the serum of lung cancer patients and in selected persons in exposed worker cohorts at risk for the development of lung cancer. Thus, the ras oncogene and p21 protein may be useful biomarkers for monitoring pulmonary carcinogenesis in exposed populations.
由于职业和环境暴露于化学致癌物（如多环芳烃）而导致的肺癌发生，为研究可能的癌基因相关癌症生物标志物提供了一个有趣的模型。多环芳烃是重要的呼吸道致癌物，已被证明会导致特定的突变损伤，从而导致ras癌基因的激活及其p21蛋白产物的表达；在人类肺癌中经常检测到ras癌基因激活和p21表达。此外，通过免疫印迹技术可在肺癌患者血清以及有患肺癌风险的暴露工人队列中的特定人群中检测到p21蛋白。因此，ras癌基因和p21蛋白可能是监测暴露人群肺癌发生的有用生物标志物。
