Qadri S M, Ali S I, Flournoy D J, Miskeen A K, Tharwat J D, Miller J
Microbiology Labs, King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
J Okla State Med Assoc. 1991 Oct;84(10):499-502.
Many bacteria are known to develop resistance to anti-microbial agents following their clinical use. The resistance pattern varies from one geographic location to another depending upon the patient population and local history of antibiotic use. The bacterial resistance to commonly used antimicrobial agents in Oklahoma City was found to be different from two cities in Saudi Arabia, especially amongst Gram-negative bacilli. A total of 13,575 fresh clinical isolates from the Veterans Administration Medical Center (VAMC), Oklahoma City, Oklahoma; the King Faisal Specialist Hospital and Research Centre (KFSH), Riyadh; and the King Fahad Hospital (KFH), Medina, Saudi Arabia; were used. There were 6,270 isolates of Enterobacteriaceae, 2,799 pseudomonads and Acinetobacter, and 4,506 Gram positive strains of staphylococcus bacteria. Gram-negative bacteria from KFH were considerably more resistant to ampicillin, gentamicin, and trimethoprim-sulfamethoxazole than at KFSH and VAMC. On the other hand, Staphylococcus aureus isolated from VAMC exhibited a significantly higher degree of resistance to oxacillin and trimethoprim-sulfamethoxazole than those at KFSH and KFH.
众所周知，许多细菌在临床使用抗菌药物后会产生耐药性。耐药模式因地理位置而异，这取决于患者群体和当地抗生素使用历史。俄克拉荷马城常用抗菌药物的细菌耐药性与沙特阿拉伯的两个城市不同，尤其是在革兰氏阴性杆菌中。总共使用了来自俄克拉荷马州俄克拉荷马城退伍军人管理局医疗中心（VAMC）、利雅得国王费萨尔专科医院和研究中心（KFSH）以及沙特阿拉伯麦地那法赫德国王医院（KFH）的13575份新鲜临床分离株。其中有6270株肠杆菌科细菌、2799株假单胞菌和不动杆菌，以及4506株革兰氏阳性葡萄球菌。KFH的革兰氏阴性菌对氨苄西林、庆大霉素和甲氧苄啶-磺胺甲恶唑的耐药性比KFSH和VAMC的要高得多。另一方面，从VAMC分离出的金黄色葡萄球菌对苯唑西林和甲氧苄啶-磺胺甲恶唑的耐药程度明显高于KFSH和KFH的。
