Qadri S M, Huber T W, Lee G C, al-Hajjar S
King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Tex Med. 1994 Nov;90(11):59-62.
Antimicrobial resistance of bacterial pathogens usually varies from one geographic location to another. During the last 20 years, outbreaks of disease caused by multiresistant bacteria have occurred with higher frequency in developing countries. We investigated the antimicrobial resistance patterns of bacteria isolated in 1992 from two tertiary-care centers, in Riyadh and Texas. Of the 8841 strains used, 5318 were isolated from clinical specimens of patients at King Faisal Specialist Hospital and Research Centre, Riyadh, and 3523 were from Olin E. Teague Veterans Medical Center, Temple, Tex. Members of Enterobacteriaceae at the King Faisal hospital were significantly more resistant to frequently prescribed antimicrobials than were those at the Olin Teague center. Susceptibility to less frequently used agents like ciprofloxacin and ceftazidime was similar at both hospitals. Resistance patterns of Pseudomonas aeruginosa, Haemophilus influenzae, and coagulase-negative staphylococci were similar at both medical centers. The Olin Teague center encountered significantly more methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci.
细菌病原体的抗菌耐药性通常因地理位置而异。在过去20年中，多重耐药菌引起的疾病暴发在发展中国家更为频繁。我们调查了1992年从利雅得和得克萨斯州的两个三级医疗中心分离出的细菌的抗菌耐药模式。在所使用的8841株菌株中，5318株是从利雅得法赫德国王专科医院和研究中心患者的临床标本中分离出来的，3523株来自得克萨斯州坦普尔的奥林·E·蒂格退伍军人医疗中心。法赫德国王医院的肠杆菌科成员对常用抗菌药物的耐药性明显高于奥林·蒂格中心的成员。两家医院对环丙沙星和头孢他啶等较少使用的药物的敏感性相似。两个医疗中心的铜绿假单胞菌、流感嗜血杆菌和凝固酶阴性葡萄球菌的耐药模式相似。奥林·蒂格中心发现的耐甲氧西林金黄色葡萄球菌和耐万古霉素肠球菌明显更多。
