Kanitakis J
Department of Dermatology, Ed. Herriot Hospital, Lyon, France.
J Eur Acad Dermatol Venereol. 2007 May;21(5):581-90. doi: 10.1111/j.1468-3083.2007.02154.x.
Paget's disease is an intra-epidermal adenocarcinoma seen over the nipple/areola (mammary Paget's disease) or in extramammary body zones, such as the anogenital and perineal skin and the axilla. Mammary and extramammary Paget's disease share many common clinicopathological features but also show several differences, namely, with regard to pathogenesis and association with underlying malignancies. Indeed, mammary Paget's disease is as a rule associated with an underlying breast carcinoma whereas association of extramammary Paget's disease with underlying (skin or visceral) malignancies occurs much less frequently. We review here the main clinicopathological and therapeutic features of mammary and extramammary Paget's disease.
佩吉特病是一种发生于乳头/乳晕（乳腺佩吉特病）或乳腺外身体部位（如肛门生殖器、会阴皮肤及腋窝）的表皮内腺癌。乳腺佩吉特病和乳腺外佩吉特病有许多共同的临床病理特征，但也存在一些差异，特别是在发病机制以及与潜在恶性肿瘤的关联方面。实际上，乳腺佩吉特病通常与潜在的乳腺癌相关，而乳腺外佩吉特病与潜在（皮肤或内脏）恶性肿瘤的关联则较少见。在此，我们回顾乳腺佩吉特病和乳腺外佩吉特病的主要临床病理及治疗特征。
