Hasebe T, Yamamichi N, Konishi F, Mukawa A
Dept. of Pathology, Kanazawa Medical Univ.
Gan No Rinsho. 1988 Feb;34(2):159-66.
Fourteen cases of extramammary Paget's disease and five cases of mammary Paget's disease have been studied using stereomorphometric, histochemical, and immunohistochemical methods. The antibodies were anti-CEA, anti-EMA, 115D8 and DF3. Intracytoplasmic mucin was positive in Paget's cells, and both 115D8 and DF3 were detected intensely in all of Paget's cells. 115D8 and DF3 were also positive in the normal apocrine sweat gland, the intercellular canaliculi of the eccrine sweat gland, and the intraductal carcinoma of the breast. Therefore, we have concluded that extramammary Paget's disease is an intraepidermal adenocarcinoma originating in the apocrine sweat gland.
采用体视形态学、组织化学和免疫组织化学方法对14例乳房外佩吉特病和5例乳房佩吉特病进行了研究。所用抗体为抗癌胚抗原（CEA）、抗上皮膜抗原（EMA）、115D8和DF3。佩吉特细胞内的胞质黏液呈阳性，所有佩吉特细胞中均强烈检测到115D8和DF3。115D8和DF3在正常顶泌汗腺、小汗腺的细胞间小管以及乳腺导管内癌中也呈阳性。因此，我们得出结论，乳房外佩吉特病是一种起源于顶泌汗腺的表皮内腺癌。
