Piérard-Franchimont C, Paquet P, Quatresooz P, Piérard G E
Department of Dermatopathology, University Hospital of Liège, Belgium.
J Eur Acad Dermatol Venereol. 2007 May;21(5):657-61. doi: 10.1111/j.1468-3083.2006.02048.x.
The observation of photo-exposed skin under ultraviolet light reveals a mosaic pattern of varying intensity in epidermal melanization. Several patterns of mosaic subclinical melanoderma (MSM) have been described using a specially designed CCD camera and the ultraviolet light-enhanced visualization (ULEV) method. Vitamin D(3) and its analogues influence the biology of keratinocytes and melanocytes.
To assess the effect of calcipotriol on MSM.
This randomized split-face study was conducted in 27 men to compare the effect of once daily applications of 5% calcipotriol cream or a moisturizing cream on the heterogeneity of facial MSM. Computerized image analysis of video images was used at 1-month intervals before and during a 2-month treatment, as well as during a 3-month follow-up.
At both sites, the average melanin content of the epidermis showed no significant change over time. However, the mottled appearance was smoothened at the calcipotriol site, whereas it was increased at the site receiving the moisturizer.
The decreased heterogeneity in MSM after calcipotriol applications suggests a control of the epidermal melanocyte unit by the vitamin D(3) derivative.
在紫外线照射下观察暴露于光的皮肤，可发现表皮黑素沉着呈现出强度各异的镶嵌图案。使用专门设计的电荷耦合器件（CCD）相机和紫外线增强可视化（ULEV）方法，已描述了几种镶嵌性亚临床黑皮病（MSM）的图案。维生素D(3)及其类似物会影响角质形成细胞和黑素细胞的生物学特性。
评估卡泊三醇对MSM的影响。
对27名男性进行了这项随机半脸研究，以比较每日一次涂抹5%卡泊三醇乳膏或保湿霜对面部MSM异质性的影响。在为期2个月的治疗前、治疗期间以及3个月的随访期间，每隔1个月使用计算机对视频图像进行图像分析。
在两个部位，表皮的平均黑色素含量随时间均无显著变化。然而，卡泊三醇涂抹部位的斑驳外观变得平滑，而使用保湿霜部位的斑驳外观则有所增加。
涂抹卡泊三醇后MSM异质性降低，表明维生素D(3)衍生物可控制表皮黑素细胞单位。
