Seckin Dilek, Cerman Asli Aksu, Yildiz Ayfer, Ergun Tulin
Marmara University School of Medicine, Department of Dermatology, Istanbul,Turkey.
J Drugs Dermatol. 2009 May;8(5):451-4.
Recent research demonstrated that vitamin D, apart from calcium-related actions, has antiproliferative, prodifferentia-tive and immunomodulatory activities.
To determine whether actinic keratoses may benefit from the antiproliferative and prodifferentiative effects of topical vitamin D.
The study was an investigator-blinded, half-side comparison trial. Patients applied calcipotriol cream to one side and Ultrabase cream as placebo to the other side of the scalp and/or face for 12 weeks. The total number of actinic keratoses (AKs), diameters and total scores of the target lesions were determined at each visit.
Nine patients were included, eight of whom completed the treatment. There was a statistically significant difference between the total number of AKs at baseline and at week 12 on calcipotriol applied side whereas no difference was detected on placebo applied side (p = 0.028 vs p = 1.00). The mean total score of the target lesions reduced significantly at week 12 on calcipotriol side; however, no significant reduction was found on placebo side (p = 0.017 vs p = 0.056). Although side effects were more common on calcipotriol side, the difference was not statistically significant.
Topical calcipotriol may show promise in the treatment of actinic keratoses. More studies are needed to confirm its efficacy.
近期研究表明，维生素D除了具有与钙相关的作用外，还具有抗增殖、促分化和免疫调节活性。
确定光化性角化病是否能从局部应用维生素D的抗增殖和促分化作用中获益。
本研究为研究者盲法、半侧对照试验。患者在头皮和/或面部的一侧涂抹卡泊三醇乳膏，另一侧涂抹作为安慰剂的超基质乳膏，持续12周。每次就诊时确定光化性角化病（AK）的总数、目标皮损的直径和总分。
纳入9例患者，其中8例完成治疗。在应用卡泊三醇的一侧，基线时和第12周时AK的总数存在统计学显著差异，而在应用安慰剂的一侧未检测到差异（p = 0.028对p = 1.00）。在第12周时，卡泊三醇一侧目标皮损的平均总分显著降低；然而，安慰剂一侧未发现显著降低（p = 0.017对p = 0.056）。虽然卡泊三醇一侧的副作用更常见，但差异无统计学意义。
局部应用卡泊三醇在治疗光化性角化病方面可能有前景。需要更多研究来证实其疗效。
