Pinder S E, Provenzano E, Earl H, Ellis I O
Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Histopathology. 2007 Mar;50(4):409-17. doi: 10.1111/j.1365-2559.2006.02419.x.
Neoadjuvant chemotherapy is increasingly being offered to patients with invasive breast carcinoma but surgical excision specimens following such therapy may be difficult to interpret in the pathology laboratory, both macroscopically and histologically. We provide here some guidelines for handling such postneoadjuvant chemotherapy samples and describe the histopathological features which may be encountered in both the breast and lymph nodes received. We also present a brief review of the literature and suggest a simple method for quantifying the degree of response to neoadjuvant chemotherapy in both the primary breast carcinoma and the lymph nodes.
新辅助化疗越来越多地应用于浸润性乳腺癌患者，但经此类治疗后的手术切除标本在病理实验室中可能难以从宏观和组织学上进行解读。我们在此提供一些处理此类新辅助化疗后样本的指南，并描述在接收的乳腺和淋巴结中可能遇到的组织病理学特征。我们还简要回顾了文献，并提出一种简单的方法来量化原发性乳腺癌和淋巴结对新辅助化疗的反应程度。
