构建更好的哮喘小鼠模型。
Building better mouse models of asthma.
作者信息
Lloyd Clare M
机构信息
Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London SW7 2AZ, England.
出版信息
Curr Allergy Asthma Rep. 2007 Jun;7(3):231-6. doi: 10.1007/s11882-007-0077-0.
Abstract
Allergic asthma is a complex disease that has been modeled extensively in small rodents. Airway eosinophilia and changes in lung function have been documented using a variety of protocols. However, recent efforts have improved these models by trying to replicate the structural remodeling that occurs in the lung as a consequence of chronic allergen-driven inflammation. This review documents the recent developments in protocols and systems designed to examine pathways leading to allergen-induced airway remodeling.
摘要
过敏性哮喘是一种复杂的疾病，已经在小型啮齿动物中进行了广泛的模型研究。使用多种方案记录了气道嗜酸性粒细胞增多和肺功能变化。然而，最近的研究通过试图复制慢性过敏原驱动的炎症导致的肺部结构重塑来改进这些模型。这篇综述记录了旨在研究导致过敏原诱导的气道重塑途径的方案和系统的最新进展。
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本文引用的文献
1
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Proc Am Thorac Soc. 2006 Jul;3(5):418-23. doi: 10.1513/pats.200602-017AW.
2
Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium.变应原诱导的气道上皮中由IκB激酶β依赖性基因介导的支气管周围纤维化和黏液分泌
Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17723-8. doi: 10.1073/pnas.0509235102. Epub 2005 Nov 29.
3
Involvement of distal airways in a chronic model of experimental asthma.远端气道在实验性哮喘慢性模型中的参与情况。
Clin Exp Allergy. 2005 Oct;35(10):1263-71. doi: 10.1111/j.1365-2222.2005.02306.x.
4
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Am J Respir Crit Care Med. 2005 Aug 1;172(3):314-21. doi: 10.1164/rccm.200502-198OC. Epub 2005 May 5.
5
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J Immunol. 2005 May 1;174(9):5774-80. doi: 10.4049/jimmunol.174.9.5774.
6
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J Immunol. 2004 Nov 15;173(10):6384-92. doi: 10.4049/jimmunol.173.10.6384.
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