France C, Ditto B, Adler P
Department of Psychology, Ohio University, Athens 45701-2979.
J Behav Med. 1991 Oct;14(5):513-25. doi: 10.1007/BF00845108.
Healthy males with a parental history of hypertension (PH+) showed reduced pain sensitivity to a constrictive thigh-cuff pressure stimulus as compared to individuals without a parental history of hypertension. The protocol included eight trials in which a thigh-cuff was inflated until the subject reported the stimulus to be "painful." The PH+ group exhibited significantly lower pain sensitivity as indicated by (1) higher levels of constrictive pressure when pain was first reported and (2) lower subjective pain ratings at maximum constrictive pressure. To assess the role of baroreflex stimulation on pain sensitivity in these groups, four trials were administered concurrently with external carotid pressure stimulation. There were no significant differences in pain sensitivity in each group as a function of baroreflex stimulation. The results suggest that the hypoalgesia observed in hypertensives may predate the development of sustained elevations in blood pressure.
与无高血压家族史的个体相比，有高血压家族史（PH+）的健康男性对大腿袖带收缩压刺激的疼痛敏感性降低。该方案包括八项试验，在试验中，将大腿袖带充气，直到受试者报告刺激为“疼痛”。PH+组表现出明显较低的疼痛敏感性，表现为：（1）首次报告疼痛时收缩压水平较高；（2）最大收缩压时主观疼痛评分较低。为了评估压力感受器反射刺激对这些组疼痛敏感性的作用，在进行四项试验的同时进行颈外动脉压力刺激。每组中，作为压力感受器反射刺激的一项功能，疼痛敏感性没有显著差异。结果表明，在高血压患者中观察到的痛觉减退可能早于血压持续升高的发生。
