Waterman A E, Livingston A, Amin A
Department of Veterinary Surgery, University of Bristol, UK.
J Vet Pharmacol Ther. 1991 Sep;14(3):230-4. doi: 10.1111/j.1365-2885.1991.tb00831.x.
The thermal and mechanical analgesic profile of buprenorphine at a dose rate of 1.5 micrograms/kg i.v. was investigated in five sheep. This dose produced significant analgesia for 40 min against the thermal stimulus, but no mechanical antinociception. A higher dose rate of 12 micrograms/kg also failed to produce antinociception to a mechanical stimulus. In addition, the effect of the drug (6 micrograms/kg) on respiratory gas tensions was determined and no significant changes were observed.
以1.5微克/千克的静脉注射剂量率，对五只绵羊研究了丁丙诺啡的热镇痛和机械镇痛情况。该剂量对热刺激产生了40分钟的显著镇痛效果，但对机械刺激没有抗伤害感受作用。12微克/千克的较高剂量率也未能对机械刺激产生抗伤害感受作用。此外，测定了该药物（6微克/千克）对呼吸气体张力的影响，未观察到显著变化。
