Waterman A E, Livingston A, Amin A
Department of Veterinary Surgery, University of Bristol, Avon.
Res Vet Sci. 1991 Jul;51(1):19-23. doi: 10.1016/0034-5288(91)90024-i.
The analgesic drug butorphanol tartrate has proved useful clinically in horses and dogs but its analgesic profile had not yet been investigated in sheep. This study was initiated to determine the thermal and mechanical antinociceptive activity of butorphanol (at the dose rates 0.05, 0.1 and 0.2 mg kg-1) in sheep. The drug produced significant analgesia in the thermal test system, the duration of which was dose related but no significant elevation in mechanical pressure thresholds could be detected. In a further set of experiments the dose rate was increased to 0.4 mg kg-1 and mechanical testing was repeated. There was still no clinically significant elevation in pressure thresholds. At a dose rate of 0.2 mg kg-1 the drug had no detectable effect on respiratory blood gas tensions. Behavioural changes were severe if a dose rate of 0.2 mg kg-1 was exceeded.
镇痛药酒石酸布托啡诺已被证明在马和狗的临床治疗中有用，但尚未在绵羊身上研究其镇痛情况。开展这项研究以确定布托啡诺（剂量率为0.05、0.1和0.2毫克/千克）在绵羊身上的热和机械性抗伤害感受活性。该药物在热测试系统中产生了显著的镇痛作用，其持续时间与剂量相关，但未检测到机械压力阈值有显著升高。在另一组实验中，剂量率增加到0.4毫克/千克，并重复进行机械测试。压力阈值仍未出现临床上显著的升高。在剂量率为0.2毫克/千克时，该药物对呼吸血气张力没有可检测到的影响。如果超过0.2毫克/千克的剂量率，行为变化会很严重。
