X射线晶体学揭示的视紫红质和9-顺式视紫红质的光异构化机制。
Photoisomerization mechanism of rhodopsin and 9-cis-rhodopsin revealed by x-ray crystallography.
作者信息
Nakamichi Hitoshi, Buss Volker, Okada Tetsuji
机构信息
Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan.
出版信息
Biophys J. 2007 Jun 15;92(12):L106-8. doi: 10.1529/biophysj.107.108225. Epub 2007 Apr 20.
Abstract
The primary photochemical process of the visual function has been investigated using the three crystallographic models, 11-cis-rhodopsin, all-trans-bathorhodopsin, and the artificial isomeric 9-cis-rhodopsin. Detailed examination of the atomic displacements and dihedral angle changes of the retinal chromophore involved in the interconversion among these isomers suggests the mechanism of isomerization efficiency.
摘要
利用三种晶体学模型，即11-顺式视紫红质、全反式视紫红质和人工异构的9-顺式视紫红质，对视觉功能的初级光化学过程进行了研究。对参与这些异构体相互转化的视黄醛发色团的原子位移和二面角变化的详细研究揭示了异构化效率的机制。
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