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本文引用的文献

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X-ray crystallographic analysis of 9-cis-rhodopsin, a model analogue visual pigment.9-顺式视紫红质（一种模拟视觉色素类似物）的X射线晶体学分析。
Photochem Photobiol. 2007 Mar-Apr;83(2):232-5. doi: 10.1562/2006-13-RA-920.
2
Protein assistance in the photoisomerization of rhodopsin and 9-cis-rhodopsin--insights from experiment and theory.视紫红质和9-顺式视紫红质光异构化过程中的蛋白质辅助作用——来自实验与理论的见解
J Am Chem Soc. 2007 Feb 7;129(5):1052-4. doi: 10.1021/ja066970p.
3
Crystallographic analysis of primary visual photochemistry.初级视觉光化学的晶体学分析
Angew Chem Int Ed Engl. 2006 Jun 26;45(26):4270-3. doi: 10.1002/anie.200600595.
4
Origin and consequences of steric strain in the rhodopsin binding pocket.视紫红质结合口袋中空间位阻的起源与后果。
Biochemistry. 2006 Jan 24;45(3):801-10. doi: 10.1021/bi0515624.
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Structure of bovine rhodopsin in a trigonal crystal form.三角晶型牛视紫红质的结构
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The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure.基于新的2.2埃晶体结构对视紫红质中视网膜的构象及其环境的研究
J Mol Biol. 2004 Sep 10;342(2):571-83. doi: 10.1016/j.jmb.2004.07.044.
7
Evidence for a common BATHO-intermediate in the bleaching of rhodopsin and isorhodopsin.
Vision Res. 1984;24(11):1465-70. doi: 10.1016/0042-6989(84)90307-9.
8
The nature of the primary photochemical events in rhodopsin and isorhodopsin.视紫红质和异视紫红质中初级光化学事件的本质。
Biophys J. 1988 Mar;53(3):367-85. doi: 10.1016/S0006-3495(88)83114-X.
9
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Biochim Biophys Acta. 1990 Apr 26;1016(3):293-327. doi: 10.1016/0005-2728(90)90163-x.
10
Effect of protonation on the isomerization properties of n-butylamine Schiff base of isomeric retinal as revealed by direct HPLC analyses: selection of isomerization pathways by retinal proteins.直接高效液相色谱分析揭示质子化对同分异构视黄醛的正丁胺席夫碱异构化性质的影响：视黄醛蛋白对异构化途径的选择
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X射线晶体学揭示的视紫红质和9-顺式视紫红质的光异构化机制。

Photoisomerization mechanism of rhodopsin and 9-cis-rhodopsin revealed by x-ray crystallography.

作者信息

Nakamichi Hitoshi, Buss Volker, Okada Tetsuji

机构信息

Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan.

出版信息

Biophys J. 2007 Jun 15;92(12):L106-8. doi: 10.1529/biophysj.107.108225. Epub 2007 Apr 20.

DOI:10.1529/biophysj.107.108225
PMID:17449675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1877761/
Abstract

The primary photochemical process of the visual function has been investigated using the three crystallographic models, 11-cis-rhodopsin, all-trans-bathorhodopsin, and the artificial isomeric 9-cis-rhodopsin. Detailed examination of the atomic displacements and dihedral angle changes of the retinal chromophore involved in the interconversion among these isomers suggests the mechanism of isomerization efficiency.

摘要

利用三种晶体学模型，即11-顺式视紫红质、全反式视紫红质和人工异构的9-顺式视紫红质，对视觉功能的初级光化学过程进行了研究。对参与这些异构体相互转化的视黄醛发色团的原子位移和二面角变化的详细研究揭示了异构化效率的机制。