Chong Semin, Lee Kyung Soo, Kim Byung-Tae, Choi Joon Young, Yi Chin A, Chung Myung Jin, Oh Dae-Kun, Lee Ji-Young
Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Ilwon-dong, Kangnam-gu, Seoul, South Korea, 135-710.
AJR Am J Roentgenol. 2007 May;188(5):1223-31. doi: 10.2214/AJR.06.0503.
The purpose of this study was to describe retrospectively integrated PET/CT findings on pulmonary neuroendocrine tumors and to correlate the findings with prognosis.
Between May 2003 and February 2005, 37 consecutively enrolled patients (33 men and four women; mean age, 60 years) with histopathologically proven pulmonary neuroendocrine tumors underwent 18F-FDG PET/CT after enhanced standalone CT. CT was used to analyze the morphologic features of the tumors and PET to measure maximum standardized uptake value (SUV). Maximum SUVs of carcinoid tumors, large-cell neuroendocrine carcinomas (LCNECs), and small-cell lung carcinomas (SCLCs) were compared, and maximum SUV and tumor stage and prognosis were correlated.
Four (two typical and two atypical) of the seven carcinoid tumors had no FDG uptake or less than mediastinal uptake. The maximum SUVs of primary tumors, in increasing order, were significantly different for carcinoids (mean, 4.0; median, 3.4), LCNECs (mean, 12.0; median, 10.7), and SCLCs (mean, 11.6; median, 11.7) (p = 0.006, Kruskal-Wallis test). There was no significant correlation between maximum SUV of the primary tumor and the tumor stages of carcinoids, LCNECs, or SCLCs (p = 0.08, Jonckheere-Terpstra test; p = 0.768, Mann-Whitney test). Results of receiver operating characteristics analysis showed a maximum SUV greater than 13.7 suggested a poor survival period in cases of LCNEC and SCLC.
The maximum SUVs of neuroendocrine tumors are significantly different for carcinoid tumors, LCNECs, and SCLCs, and a high maximum SUV suggests short survival of patients with LCNEC or SCLC.
本研究的目的是回顾性描述肺神经内分泌肿瘤的PET/CT综合表现，并将这些表现与预后相关联。
2003年5月至2005年2月期间，37例经组织病理学证实的肺神经内分泌肿瘤患者（33例男性，4例女性；平均年龄60岁）在增强型独立CT检查后接受了18F-FDG PET/CT检查。CT用于分析肿瘤的形态学特征，PET用于测量最大标准化摄取值（SUV）。比较类癌、大细胞神经内分泌癌（LCNEC）和小细胞肺癌（SCLC）的最大SUV，并将最大SUV与肿瘤分期及预后相关联。
7例类癌中有4例（2例典型类癌和2例非典型类癌）无FDG摄取或摄取低于纵隔。类癌（平均4.0；中位数3.4）、LCNEC（平均12.0；中位数10.7）和SCLC（平均11.6；中位数11.7）的原发肿瘤最大SUV按升序排列有显著差异（p = 0.006，Kruskal-Wallis检验）。原发肿瘤的最大SUV与类癌、LCNEC或SCLC的肿瘤分期之间无显著相关性（p = 0.08，Jonckheere-Terpstra检验；p = 0.768，Mann-Whitney检验）。受试者工作特征分析结果显示，最大SUV大于13.7提示LCNEC和SCLC患者生存期较差。
类癌、LCNEC和SCLC的神经内分泌肿瘤最大SUV有显著差异，高最大SUV提示LCNEC或SCLC患者生存期短。
