Michel R T, Schmidt-Matthiesen H, Nord D, Bastert G, Gerner R
Arch Gynakol. 1975 Dec 16;220(1):55-64. doi: 10.1007/BF00673148.
In 30 cases of breast-cancer, including 24 primary cases, the tumor-associted fibrinolysis was investigated using agar plate method. In 60% of the tissue sample fibrinolytic activity was found. No activity could be detected in the remaining 40%. There was evidence of a positive correlation between tumor-associated fibrinolysis and tumor size as well as the rate of axilla metastases. Among the fibrinolytic active cases there was a disproporionate number of adenocarcinoma, whereas in the inactive collective the solid and scirrhous carcinoma prevailed. There was no relation between the tumor-associated fibrinolysis and the percentage of tumor cells in the tissue. The firbinolytic inactive tumors showed a better histopathological adaptation to the surrounding tissue than the active ones. There was less small-cell infiltrate in the stroma of the fibrinolytic active tumors than in the inactive cases. No significant difference was found in the form of growth and the occurence of fibre structure. For clinical assessment a longer period of observation and a larger study are necessary.
在30例乳腺癌患者中（包括24例原发性病例），采用琼脂平板法对肿瘤相关纤溶作用进行了研究。在60%的组织样本中发现了纤溶活性。其余40%未检测到活性。有证据表明肿瘤相关纤溶作用与肿瘤大小以及腋窝转移率之间存在正相关。在纤溶活性病例中，腺癌的比例不成比例，而在无活性的病例组中，实性癌和硬癌占主导。肿瘤相关纤溶作用与组织中肿瘤细胞的百分比之间没有关系。纤溶无活性的肿瘤在组织病理学上比活性肿瘤对周围组织的适应性更好。与无活性病例相比，纤溶活性肿瘤间质中的小细胞浸润较少。在生长形式和纤维结构的出现方面未发现显著差异。为了进行临床评估，需要更长的观察期和更大规模的研究。
