Iida T
Department of Surgery, Tokyo Women's Medical College, Danini Hospital, Japan.
Nihon Geka Gakkai Zasshi. 1989 Jun;90(6):914-9.
The content of hydroxyproline was determined in cancerous and noncancerous tissues obtained from 40 patients with primary breast cancer, and investigated from a clinicopathologic viewpoint. The level of hydroxyproline in cancerous tissue was higher than that in normal mammary gland, but was lower than that of the tissue of mastopathy. In relation to the histologic type, the level was the highest in scirrhous carcinoma, followed by papillotubular and solid tubular carcinoma. With regard to lymph node metastasis, the hydroxyproline level was significantly higher in positive than in negative metastatic cases. The corresponding level tended to be higher in patients at stages II-IV than in those at stage I. There was no obvious relationship to tumor size. However, a significant, negative correlation was found between the hydroxyproline level and patient age. Thus, the content of hydroxyproline was found to be closely related to age and clinicopathologic factors such as the histologic type and degree of lymph node metastasis.
对40例原发性乳腺癌患者的癌组织和非癌组织中的羟脯氨酸含量进行了测定，并从临床病理学角度进行了研究。癌组织中羟脯氨酸水平高于正常乳腺组织，但低于乳腺病组织。就组织学类型而言，硬癌中羟脯氨酸水平最高，其次是乳头管状癌和实体管状癌。关于淋巴结转移，阳性转移病例中的羟脯氨酸水平显著高于阴性转移病例。Ⅱ-Ⅳ期患者的相应水平往往高于Ⅰ期患者。与肿瘤大小无明显关系。然而，发现羟脯氨酸水平与患者年龄呈显著负相关。因此，发现羟脯氨酸含量与年龄以及组织学类型和淋巴结转移程度等临床病理因素密切相关。
