Aurlien H, Aarseth J H, Gjerde I O, Karlsen B, Skeidsvoll H, Gilhus N E
Section of Clinical Neurophysiology, Department of Neurology, Haukeland University Hospital, Bergen, Norway.
Clin Neurophysiol. 2007 Jun;118(6):1369-76. doi: 10.1016/j.clinph.2007.02.027. Epub 2007 Apr 23.
To study the age-related topographical tendency of expressing epileptiform activity, and the effect of focal epileptiform activity (FEA) on the general cortical brain activity.
1647 consecutive routine EEGs containing FEA were visually assessed for FEA location and asymmetry. Background activity was compared with that in normal EEGs from 3268 drug-free outpatient controls.
FEA localisation was age-related (p<0.0005) except for the temporal region (p=0.22) where FEA was found equally often in the young and the old. The left hemisphere was more prone to FEA (p=0.018). The left-right asymmetry varied by age (p=0.013). FEA asymmetry occurred most frequently in EEGs from patients older than 80 years, and least frequent in the age-group 20-39 years. FEA was associated with lower alpha rhythm (AR) frequencies (p=0.0041) and higher AR amplitudes (p=0.0023), as well as higher general background activity (GBA) amplitude (p<0.0005), while GBA frequencies were the same (p=0.96).
Topographical localisation of FEA was age-dependent. There was an overall left dominance, but the side asymmetry was modest and varied by age. FEA was associated with changes in AR and GBA.
The results demonstrate that FEA is associated with cerebral cortical dysfunction also distant from the epileptic focus.
研究癫痫样活动表达的年龄相关地形学倾向，以及局灶性癫痫样活动（FEA）对大脑皮质整体活动的影响。
对1647份连续的包含FEA的常规脑电图进行视觉评估，以确定FEA的位置和不对称性。将背景活动与来自3268名无药物治疗的门诊对照者的正常脑电图进行比较。
除颞叶区域外，FEA的定位与年龄相关（p<0.0005），在颞叶区域，FEA在年轻人和老年人中出现的频率相同（p=0.22）。左半球更容易出现FEA（p=0.018）。左右不对称性随年龄而异（p=0.013）。FEA不对称性在80岁以上患者的脑电图中出现频率最高，在20-39岁年龄组中出现频率最低。FEA与较低的α波节律（AR）频率（p=0.0041）和较高的AR波幅（p=0.0023）相关，同时也与较高的整体背景活动（GBA）波幅相关（p<0.0005），而GBA频率相同（p=0.96）。
FEA的地形学定位与年龄有关。总体上以左侧为主，但侧别不对称性较小且随年龄而异。FEA与AR和GBA的变化相关。
结果表明，FEA还与远离癫痫灶的大脑皮质功能障碍有关。
