通过扩散张量磁共振成像检测到的骨骼肌与年龄相关的变化。

Age-related changes in skeletal muscle as detected by diffusion tensor magnetic resonance imaging.

作者信息

Galbán Craig J, Maderwald Stefan, Stock Frank, Ladd Mark E

机构信息

Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital of Essen, Germany.

出版信息

J Gerontol A Biol Sci Med Sci. 2007 Apr;62(4):453-8. doi: 10.1093/gerona/62.4.453.

DOI:10.1093/gerona/62.4.453

PMID:17452742

Abstract

BACKGROUND

Loss of muscle mass and strength is a common symptom in the elderly population. This is partly a result of the structural changes that occur during the aging process. We applied diffusion tensor magnetic resonance imaging (DTMRI) to determine if water diffusivity in skeletal muscle changes with age.

METHODS

Thirty-eight healthy men, ranging from 27 to 67 years of age, were recruited for this study. The total population was grouped by age (Young < mean age 46.4: n = 20; Old > or = mean age 46.4: n = 18) and body mass index (BMI; Normal < 25: n = 20; Over > or =25: n = 18). The principal, second, and third eigenvalues (lambda(1) > or = lambda(2) > or = lambda(3)), and fractional anisotropy (FA), were calculated from the diffusion tensor of the soleus, lateral and medial gastrocnemius, and anterior tibialis (AT). Analyses included comparison of groups and linear regressions.

RESULTS

The older adults showed a significant reduction in the eigenvalues of the plantar flexors ( approximately 7%, p <.05) and FA of AT ( approximately 10%, p <.05) from that of the younger adults. No age differences were observed in the FA of the plantar flexors or eigenvalues of AT. lambda(1) and lambda(2) had a linear dependence on age in the plantar flexors, whereas AT showed age dependence in lambda(3) and FA.

CONCLUSIONS

We demonstrated that DTMRI is sensitive to age-related changes in muscle, and that the effects of aging differ between the plantar flexors and AT.

摘要

背景

肌肉质量和力量的丧失是老年人群中的常见症状。这部分是衰老过程中发生的结构变化的结果。我们应用扩散张量磁共振成像（DTMRI）来确定骨骼肌中的水扩散率是否随年龄变化。

方法

本研究招募了38名年龄在27至67岁之间的健康男性。总体人群按年龄（年轻组<平均年龄46.4岁：n = 20；老年组≥平均年龄46.4岁：n = 18）和体重指数（BMI；正常组<25：n = 20；超重组≥25：n = 18）进行分组。从比目鱼肌、腓肠肌外侧头和内侧头以及胫骨前肌（AT）的扩散张量计算出主、次和第三特征值（λ(1)≥λ(2)≥λ(3)）以及分数各向异性（FA）。分析包括组间比较和线性回归。