Okamoto Yoshikazu, Kemp Graham J, Isobe Tomonori, Sato Eisuke, Hirano Yuji, Shoda Junichi, Minami Manabu
Department of Radiology, Institute of Clinical Medicine, University of Tsukuba Hospital, Ibaraki, Japan.
Department of Musculoskeletal Biology, Faculty of Health & Life Sciences, University of Liverpool, Liverpool, Merseyside, United Kingdom.
Magn Reson Imaging. 2014 Dec;32(10):1297-300. doi: 10.1016/j.mri.2014.07.002. Epub 2014 Jul 31.
Several studies have proposed the cell membrane as the main water diffusion restricting factor in the skeletal muscle cell. We sought to establish whether a particular form of exercise training (which is likely to affect only intracellular components) could affect water diffusion. The purpose of this study is to characterise prospectively the changes in diffusion tensor imaging (DTI) eigenvalues of thigh muscle resulting from hybrid training (HYBT) in patients with non-alcoholic fatty liver disease (NAFLD). Twenty-one NAFLD patients underwent HYBT for 30 minutes per day, twice a week for 6 months. Patients were scanned using DTI of the thigh pre- and post-HYBT. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), the three eigenvalues lambda 1 (λ1), λ2, λ3, and the maximal cross sectional area (CSA) were measured in bilateral thigh muscles: knee flexors (biceps femoris (BF), semitendinosus (ST), semimembranous (SM)) and knee extensors (medial vastus (MV), intermediate vastus (IV), lateral vastus (LV), and rectus femoris (RF)), and compared pre- and post-HYBT by paired t-test. Muscle strength of extensors (P<0.01), but not flexors, increased significantly post-HYBT. For FA, ADC and eigenvalues, the overall picture was of increase. Some (P<0.05 in λ2 and P<0.01 in λ1) eigenvalues of flexors and all (λ1-λ3) eigenvalues of extensors increased significantly (P<0.01) post-HYBT. HYBT increased all 3 eigenvalues. We suggest this might be caused by enlargement of muscle intracellular space.
多项研究提出，细胞膜是骨骼肌细胞中限制水扩散的主要因素。我们试图确定一种特定形式的运动训练（可能仅影响细胞内成分）是否会影响水扩散。本研究的目的是前瞻性地描述非酒精性脂肪性肝病（NAFLD）患者进行混合训练（HYBT）后大腿肌肉扩散张量成像（DTI）特征值的变化。21例NAFLD患者每天进行30分钟的HYBT，每周两次，共6个月。在HYBT前后，对患者的大腿进行DTI扫描。测量双侧大腿肌肉（屈膝肌：股二头肌（BF）、半腱肌（ST）、半膜肌（SM））和伸膝肌（股内侧肌（MV）、股中间肌（IV）、股外侧肌（LV）和股直肌（RF））的分数各向异性（FA）、表观扩散系数（ADC）、三个特征值λ1、λ2、λ3以及最大横截面积（CSA），并通过配对t检验比较HYBT前后的情况。HYBT后，伸肌的肌肉力量显著增加（P<0.01），而屈肌则没有。对于FA、ADC和特征值，总体情况是增加。屈肌的一些特征值（λ2中P<0.05，λ1中P<0.01）和伸肌的所有特征值（λ1-λ3）在HYBT后显著增加（P<0.01）。HYBT增加了所有三个特征值。我们认为这可能是由于肌肉细胞内空间扩大所致。
