Bose K S C, Agrawal B K
Department of Biochemistry, People's College of Medical Sciences and Research Centre, Bhanpur, Bhopal, India.
Singapore Med J. 2007 May;48(5):415-20.
This present study aims to evaluate the beneficial effect of tomatoes, a rich source of lycopene, which is a relatively new carotenoid known to play an important role in human health and disease.
We investigated the lipid peroxidation rate by estimating malondialdehyde (MDA), levels of serum enzymes involved in antioxidant activities such as superoxide dismutase, glutathione peroxidase, glutathione reductase, reduced glutathione and lipid profile, which includes total cholesterol, triglycerides, high density lipoprotein, low density lipoprotein and very low density lipoprotein in a coronary heart disease (CHD) group and an age-matched control group.
We observed significantly lower levels of serum antioxidant enzymes and very high lipid peroxidation rate in the CHD group, when compared to the controls (p-value is less than 0.001). At the same time, we observed significantly higher levels of lipids in the CHD group, when compared to the controls (p-value is less than 0.001). 60 days of tomato supplementation in the CHD group showed a significant improvement in the levels of serum enzymes involved in antioxidant activities and decreased lipid peroxidation rate (p-value is less than 0.001), but there were no significant changes in lipid profile (p-value is greater than 0.10).
These findings suggest that tomato lycopene may have considerable therapeutic potential as an antioxidant but may not be used as a hypolipidaemic agent in CHD.
本研究旨在评估番茄的有益作用，番茄是富含番茄红素的来源，番茄红素是一种相对较新的类胡萝卜素，已知在人类健康和疾病中发挥重要作用。
我们通过估计丙二醛（MDA）来研究脂质过氧化率，以及参与抗氧化活性的血清酶水平，如超氧化物歧化酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶、还原型谷胱甘肽和脂质谱，脂质谱包括冠心病（CHD）组和年龄匹配的对照组中的总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白和极低密度脂蛋白。
与对照组相比，我们观察到冠心病组血清抗氧化酶水平显著降低，脂质过氧化率非常高（p值小于0.001）。同时，与对照组相比，我们观察到冠心病组脂质水平显著更高（p值小于0.001）。冠心病组补充番茄60天显示参与抗氧化活性的血清酶水平有显著改善，脂质过氧化率降低（p值小于0.001），但脂质谱无显著变化（p值大于0.10）。
这些发现表明，番茄红素作为抗氧化剂可能具有相当大的治疗潜力，但在冠心病中可能不能用作降血脂药物。
