College of Nursing, University of Kentucky, Lexington, KY 40536, USA.
Eur J Cardiovasc Nurs. 2013 Aug;12(4):377-84. doi: 10.1177/1474515112459601. Epub 2012 Oct 16.
The antioxidant lycopene may be beneficial for patients with heart failure (HF). Processed tomato products are a major source of lycopene, although they are also high in sodium. Increased sodium intake may counter the positive antioxidant effect of lycopene.
This was a prospective study of 212 patients with HF. Dietary intake of lycopene and sodium was obtained from weighted 4-day food diaries. Patients were grouped by the median split of lycopene of 2471 µg/day and stratified by daily sodium levels above and below 3 g/day. Patients were followed for 1 year to collect survival and hospitalization data. Cox proportional hazards modeling was used to compare cardiac event-free survival between lycopene groups within each stratum of sodium intake.
Higher lycopene intake was associated with longer cardiac event-free survival compared with lower lycopene intake (p = 0.003). The worst cardiac event-free survival was observed in the low lycopene intake group regardless of sodium intake (> 3 g/day HR = 3.01; p = 0.027 and ≤ 3 g/day HR= 3.34; p = 0.023).
These findings suggest that increased lycopene intake has the potential to improve cardiac event-free survival in patients with HF independent of sodium intake.
抗氧化剂番茄红素可能对心力衰竭（HF）患者有益。加工过的番茄制品是番茄红素的主要来源，但它们的钠含量也很高。钠的摄入量增加可能会抵消番茄红素的积极抗氧化作用。
这是一项对 212 名 HF 患者的前瞻性研究。通过加权 4 天的食物日记来获取番茄红素和钠的饮食摄入量。根据番茄红素中位数（2471μg/天）将患者分组，并根据每日钠摄入量高于和低于 3 克/天进行分层。随访 1 年以收集生存和住院数据。使用 Cox 比例风险模型比较每个钠摄入量分层中番茄红素组之间的无心脏事件生存率。
与低番茄红素摄入相比，较高的番茄红素摄入与更长的无心脏事件生存率相关（p=0.003）。无论钠摄入量如何（>3 g/天 HR=3.01；p=0.027 和≤3 g/天 HR=3.34；p=0.023），低番茄红素摄入组的无心脏事件生存率最差。
这些发现表明，增加番茄红素的摄入量有可能改善 HF 患者的无心脏事件生存率，而与钠的摄入量无关。
