Higa M, Davanipour Z
Department of Neurology, School of Medicine, Loma Linda University, Calif.
Neuroepidemiology. 1991;10(4):211-22. doi: 10.1159/000110272.
The purpose of this review is to evaluate literature published since 1978 on the association between smoking and stroke. Two cohort studies found a dose-response relationship between the amount of cigarettes smoked per day and the relative risk of stroke. Also, two of the cohort studies found that when smoking ceased, the risk of stroke lessened (p less than 0.001). Nine case-control studies found a significant association between smoking and stroke for men and women. The biological association between smoking and stroke is plausible and several epidemiologic studies are supportive of this thesis. Additional, well-designed epidemiologic studies with a sufficient sample size to detect reasonably small odds ratios or relative risks (thus providing adequate statistical power) are warranted.
本综述的目的是评估1978年以来发表的关于吸烟与中风之间关联的文献。两项队列研究发现，每天吸烟量与中风相对风险之间存在剂量反应关系。此外，两项队列研究发现，戒烟后中风风险降低（p<0.001）。九项病例对照研究发现，吸烟与男性和女性中风之间存在显著关联。吸烟与中风之间的生物学关联是合理的，多项流行病学研究支持这一论点。此外，有必要进行设计良好、样本量足够大以检测合理小的比值比或相对风险（从而提供足够统计效力）的流行病学研究。
