Maitre Marcos M, Longhi Marcela R, Granero Gladys G
Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba, Argentina.
Drug Dev Ind Pharm. 2007 Mar;33(3):311-26. doi: 10.1080/03639040600901978.
Binary and multicomponent systems complexes prepared with HP-beta-CD and/or with monoethanolamine (MEA), diethanolamine (DEA) or triethanolamine (TEA) were obtained. The results of solid-state studies indicated the presence of strong interactions between the components in the binary and the ternary systems. Drug solubility and dissolution rate in water were notably improved by employing the HP-beta-CD and the alkanolamines. The combined use of cosolvency and complexation with MEA in the presence of HP-beta-CD on the permeation of flurbiprofen through the human skin was evaluated. The combination of IPM, PG, and HP-beta-CD yield the highest permeation for the flurbiprofen-MEA complex.
制备了用羟丙基-β-环糊精（HP-β-CD）和/或用单乙醇胺（MEA）、二乙醇胺（DEA）或三乙醇胺（TEA）形成的二元和多组分体系配合物。固态研究结果表明在二元和三元体系中各组分之间存在强相互作用。通过使用HP-β-CD和链烷醇胺，药物在水中的溶解度和溶解速率得到显著提高。评估了在HP-β-CD存在下共溶剂化和与MEA络合对氟比洛芬透过人体皮肤渗透的联合作用。IPM、PG和HP-β-CD的组合使氟比洛芬-MEA配合物的渗透量最高。
