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氰化物解毒剂治疗大量伤亡：肌内注射用 3-巯基丙酮酸的二硫烯（磺萘根）水溶性盐。

Cyanide antidotes for mass casualties: water-soluble salts of the dithiane (sulfanegen) from 3-mercaptopyruvate for intramuscular administration.

机构信息

Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, Minnesota 55455, USA.

出版信息

J Med Chem. 2013 Feb 14;56(3):1346-9. doi: 10.1021/jm301633x. Epub 2013 Jan 30.

DOI:10.1021/jm301633x
PMID:23301495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3575131/
Abstract

Current cyanide antidotes are administered by IV infusion, which is suboptimal for mass casualties. Therefore, in a cyanide disaster, intramuscular (IM) injectable antidotes would be more appropriate. We report the discovery of the highly water-soluble sulfanegen triethanolamine as a promising lead for development as an IM injectable cyanide antidote.

摘要

目前的氰化物解毒剂通过静脉输注给药，对于大量伤亡情况来说并不理想。因此，在氰化物灾难中，肌肉内（IM）注射解毒剂更为合适。我们报告了高度水溶性的磺酸钠三乙醇胺的发现，它是作为一种有前途的 IM 注射用氰化物解毒剂开发的先导化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46a2/3575131/ef0a772f8dff/nihms-441034-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46a2/3575131/0ea5636e889d/nihms-441034-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46a2/3575131/9b1993a112e4/nihms-441034-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46a2/3575131/ef0a772f8dff/nihms-441034-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46a2/3575131/0ea5636e889d/nihms-441034-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46a2/3575131/9b1993a112e4/nihms-441034-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46a2/3575131/ef0a772f8dff/nihms-441034-f0003.jpg

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