重复固定应激对小鼠肾上腺嗜铬细胞中外源性[3H]多巴胺摄取的影响。
Effect of repeated immobilization stress on the uptake of exogenous [3H]dopamine in adrenal chromaffin cells of mice.
作者信息
Hirano T, Nagai K, Bando T, Nakagawa H
机构信息
Department of Physiology, Niigata University, School of Medicine, Japan.
出版信息
Neurosci Lett. 1991 Aug 19;129(2):273-6. doi: 10.1016/0304-3940(91)90479-d.
Uptake of [3H]dopamine in adrenal chromaffin cells of the mouse during repeated immobilization was examined by autoradiography. Repeated daily immobilization of mice resulted in an increased uptake of [3H]dopamine to the level of denervated chromaffin cells. The increase was observed only in adrenaline-storing (A) cells, not in noradrenaline-storing (NA) cells. The results indicate that sympathetic outflow to the adrenal gland, especially to A cells, is ceased or blocked during the adaptation to stress.
通过放射自显影术检测了反复固定期间小鼠肾上腺嗜铬细胞对[3H]多巴胺的摄取情况。每天反复固定小鼠导致[3H]多巴胺摄取增加至去神经支配嗜铬细胞的水平。这种增加仅在储存肾上腺素的（A）细胞中观察到，而在储存去甲肾上腺素的（NA）细胞中未观察到。结果表明，在适应应激过程中，肾上腺的交感神经输出，尤其是对A细胞的输出，停止或受阻。
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