在明期和暗期小鼠肾上腺髓质对[3H]多巴胺的摄取

Uptake of [3H]dopamine in the mouse adrenal medulla during dark and light period.

作者信息

Hirano T, Nagai K, Bando T, Nakagawa H, Niijima A

机构信息

Department of Physiology, Niigata University Medical School, Japan.

出版信息

J Auton Nerv Syst. 1989 Oct;28(1):89-93. doi: 10.1016/0165-1838(89)90011-8.

DOI:10.1016/0165-1838(89)90011-8

PMID:2584617

Abstract

Uptake of exogenous [3H]dopamine in adrenal chromaffin cells of the mouse was studied by autoradiography under a 12-h light, 12-h dark cycle. The uptake of [3H]dopamine in adrenal chromaffin cells was markedly decreased in the dark period. The decrease was prevented by adrenal denervation. It is postulated that there is a neurally mediated suppression of [3H]dopamine uptake by adrenal chromaffin cells in the dark period. Adrenaline-storing (A) cells are more sensitive to the decreased sympathetic activity than noradrenaline-storing (NA) cells while increased sympathetic activity non-selectively affects both types of adrenal chromaffin cells.

摘要

在12小时光照、12小时黑暗的周期条件下，通过放射自显影术研究了小鼠肾上腺嗜铬细胞对外源性[3H]多巴胺的摄取情况。在黑暗期，肾上腺嗜铬细胞对[3H]多巴胺的摄取显著减少。肾上腺去神经支配可防止这种减少。据推测，在黑暗期存在神经介导的对肾上腺嗜铬细胞摄取[3H]多巴胺的抑制作用。储存肾上腺素的（A）细胞比储存去甲肾上腺素的（NA）细胞对交感神经活动降低更敏感，而交感神经活动增加则对两种类型的肾上腺嗜铬细胞均有非选择性影响。