Brealey John K
Electron Microscope Unit, Institute of Medical & Veterinary Science, Division of Pathology, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia.
Ultrastruct Pathol. 2007 Jan-Feb;31(1):1-7. doi: 10.1080/01913120600854418.
BK virus nephropathy is a known cause of renal transplant dysfunction and failure. The disease is identified by examination of kidney biopsy tissue utilizing histopathological techniques. Ultrastructural examination of two glomeruli revealed pathology within one glomerulus. Glomerular basement membranes contained subepithelial humps of deposit-like material and BK viruses were identified within this material. Viruses were identified within intertubular capillaries. There was evidence of cytoplasmic clearance of viruses from the glomerular basement membrane by podocytes. The findings may be relevant to the investigation of hump formation and antigen clearance in BK virus nephropathy and postinfectious glomerulonephritis.
BK病毒肾病是肾移植功能障碍和衰竭的已知病因。通过利用组织病理学技术检查肾活检组织来识别该疾病。对两个肾小球进行超微结构检查发现其中一个肾小球存在病变。肾小球基底膜含有上皮下沉积物样物质驼峰，并且在该物质中鉴定出BK病毒。在肾小管间毛细血管内也发现了病毒。有证据表明足细胞可从肾小球基底膜清除病毒的细胞质。这些发现可能与BK病毒肾病和感染后肾小球肾炎中驼峰形成及抗原清除的研究相关。
