Endre L
Children's Hospital of Buda, Budapest, Hungary.
Oral Surg Oral Med Oral Pathol. 1991 Nov;72(5):559-61. doi: 10.1016/0030-4220(91)90493-v.
Zinc deficiency (serum zinc level 65 micrograms/dl) and cellular immune deficiency (confirmed by lymphoblastic transformation assay) were found in a 15-year-old boy who had had recurrent aphthous ulceration for 6 years. Despite the previous therapy (orally administered steroid, isoprinosine, interferon, lysozyme, and local treatment), the ulcers recurred monthly. After 3 months of zinc therapy (50 mg zinc sulfate orally three times daily) the aphthae disappeared and did not reappear for 1 year. The lymphoblastic transformation activity and serum zinc levels were also normalized with this treatment.
一名15岁男孩，反复发生阿弗他溃疡6年，检查发现有锌缺乏（血清锌水平为65微克/分升）及细胞免疫缺陷（经淋巴细胞转化试验证实）。尽管此前进行过治疗（口服类固醇、异丙肌苷、干扰素、溶菌酶及局部治疗），溃疡仍每月复发。锌治疗3个月（口服硫酸锌50毫克，每日3次）后，口疮消失，1年内未再复发。经此治疗，淋巴细胞转化活性及血清锌水平也恢复正常。
