Orbak Recep, Cicek Yasin, Tezel Adnan, Dogru Yusuf
Department of Periodontology, Ataturk University Faculty of Dentistry, Erzurun-Turkey.
Dent Mater J. 2003 Mar;22(1):21-9. doi: 10.4012/dmj.22.21.
The purpose of this study was to assess the effects of systemic zinc sulfate in the treatment of recurrent aphthous stomatitis (RAS) by atomic absorption spectrophotometry. The study was carried out on 40 patients with RAS. The first group consisted of 20 subjects with RAS who were administered zinc sulfate (220 mg) once per day for one month. In the second group, there were 20 subjects with RAS who were administered placebo (saccharose). Results showed that the levels of serum zinc before treatment were under the normal value in the 42.5% percent of the patients with RAS. Saliva ALP, serum zinc, serum albumin, and serum alkaline phosphates activity for group II were significantly lower than those for group I after treatment (p < 0.01). After 1 month of zinc therapy the aphthae reduced and did not reappear for 3 months. The empirical use of systemic zinc sulfate supplementation in the treatment of RAS is recommend.
本研究的目的是通过原子吸收分光光度法评估全身性硫酸锌治疗复发性阿弗他口炎（RAS）的效果。该研究对40例RAS患者进行。第一组由20名RAS受试者组成，他们每天服用一次硫酸锌（220毫克），持续一个月。第二组有20名RAS受试者，他们服用安慰剂（蔗糖）。结果显示，42.5%的RAS患者治疗前血清锌水平低于正常值。治疗后，第二组的唾液碱性磷酸酶、血清锌、血清白蛋白和血清碱性磷酸酶活性显著低于第一组（p<0.01）。锌治疗1个月后口疮减少，3个月内未复发。推荐经验性使用全身性硫酸锌补充剂治疗RAS。
